HIV-1 envelope glycoproteins : folding, function and vaccine design / Rogier Willem Sanders.

Format:

Book

Author/Creator:

Sanders, Rogier Willem.

Language:

English

Subjects (All):

HIV (Viruses).

Glycoproteins.

Physical Description:

1 online resource (338 p.)

Edition:

1st ed.

Place of Publication:

Amsterdam : Amsterdam University Press, 2004.

Language Note:

English

Summary:

The need for a vaccine against HIV is obvious, but the development of an effective vaccine has met with frustrations. The HIV envelope glycoproteins, residing in the viral membrane, are the sole viral proteins exposed on the outside of virus particles and are therefore major targets for vaccine design. The first part of this thesis describes research aimed at understanding the folding and function of the HIV-1 envelope glycoproteins and their properties underlying the effective viral immune evasion. The second part of the thesis describes the design of modifications of the envelope glycoprotei

Contents:

Table of Contents; 1 Introduction; 2 Env and HIV transmission; 3 Env antigenicity; 4 Env folding; 5 Env modifications for vaccines; 6 Concluding remarks; Appendix Mutational analyses and natural variability of the gp41 ectodomain; Summary; Samenvatting (Dutch); Dankwoord (Dutch); Publications

Notes:

Description based upon print version of record.

ISBN:

1-280-95900-2

9786610959006

90-485-0371-X

1-4175-8338-X

OCLC:

437107007