Concepts in genetic medicine / edited by Boro Dropulic, Barrie Carter.

Format:

Book

Contributor:

Dropulic, Boro.

Carter, Barrie.

Language:

English

Subjects (All):

Medical genetics.

Gene therapy.

Physical Description:

1 online resource (393 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, N.J. : Wiley-Liss, c2008.

Language Note:

English

Summary:

This book delivers a collection of organized and succinct reviews in the field of therapeutic genetic medicine presented by a carefully selected group of top experts. Each chapter focuses on a single, current topic and explains issues in the development of genetic treatments, critical challenges and strategies for implementing them, and future directions in research and translational applications. The book is complemented with uniformly designed illustrations and a supplementary Web site with a PowerPoint presentation for educators.

Contents:

CONCEPTS IN GENETIC MEDICINE; CONTENTS; CONTRIBUTORS; PREFACE; INTRODUCTION; 1 The Evolution of Human Gene Therapy: A Journey from Excessive Hype to Excessive Diffidence to Reality; VECTOR SYSTEMS; 2 Murine Leukemia Virus-Based Retroviral Vectors; 3 Lentivirus Vectors; 4 Adenoviral Vectors: History and Perspective; 5 Adeno-Associated Virus Vectors; 6 SV40 Virus-Derived Vectors; 7 Herpes Simplex Virus Vectors; 8 Nonviral Gene Delivery Systems; APPLICATIONS; 9 Therapeutic Gene Transfer to Skeletal Muscle; 10 Gene Therapy for Cardiovascular Disease

11 Intra-articular Vector Delivery for Inflammatory Joint Disease 12 The Respiratory System as a Platform for Gene Delivery; 13 The Brain as a Target for Gene Therapy; 14 Immune Responses to Viral Vectors Injected Systemically or into the CNS; 15 Cancer Vaccines; 16 Genetically Modified T Cells for Human Gene Therapy; 17 Lentiviral Vector Delivery of RNAi for the Treatment of HIV-1 Infection; 18 Vector Targeting; THE MANUFACTURE OF GENE THERAPY PRODUCTS; 19 The Manufacture of Genetic Viral Vector Products; 20 The Manufacture of Adeno-Associated Viral Vectors; 21 Lentivirus Vector Manufacturing

SAFETY AND REGULATORY CONSIDERATIONS 22 Assays for the Release of Viral Vector Gene Therapy Products for Human Clinical Trials; 23 Safety of Retroviral Vectors: Regulatory and Technical Considerations; 24 Assays for the Quality Control of Lentiviral Vectors; 25 Assays for Nonviral Vectors; 26 Assays for the Release of Cellular Gene Therapy Products; 27 Toxicology for Gene Therapy Products: Concepts and Challenges; 28 Regulatory Aspects of Gene Therapy Medicinal Products in the European Union; FINANCE AND REIMBURSEMENT; 29 Venture Capital and Biotechnology Startups

30 The Role of Investment Banking in the Growth of Biotechnology Companies 31 Managing Reimbursement for Gene Therapy Products; INDEX

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-28442-4

9786611284428

0-470-18458-2

0-470-18457-4

OCLC:

476150171