Structural and functional organization of the synapse / edited by Johannes W. Hell and Michael D. Ehlers.

Format:

Book

Contributor:

Ehlers, Michael D.

Hell, Johannes W.

Language:

English

Subjects (All):

Neural transmission.

Synapses.

Physical Description:

1 online resource (814 p.)

Edition:

1st ed. 2008.

Place of Publication:

New York : Springer, c2008.

Language Note:

English

Summary:

Synapses play a central role in the brain by mediating signal transmission between neurons. This book provides a fundamental description of the synapse by leading experts in the field. Each individual synapse carries out its numerous functions in a tiny space, thereby requiring an exquisite molecular and functional arrangement. This book describes the molecular structure and cellular function of central synapses in the brain, providing a detailed view of the brain’s fundamental unit of information storage.

Contents:

Diversity in Synapse Structure and Composition

The Role of Glutamate Transporters in Synaptic Transmission

Structure and Function of Vertebrate and Invertebrate Active Zones

Neurotransmitter Release Machinery: Components of the Neuronal SNARE Complex and Their Function

The Molecular Machinery for Synaptic Vesicle Endocytosis

Initiation and Regulation of Synaptic Transmission by Presynaptic Calcium Channel Signaling Complexes

Adhesion Molecules at the Synapse

Dendritic Organelles for Postsynaptic Trafficking

Structure and Mechanism of Action of AMPA and Kainate Receptors

Cellular Biology of AMPA Receptor Trafficking and Synaptic Plasticity

Structure and Function of the NMDA Receptor

Molecular Properties and Cell Biology of the NMDA Receptor

Surface Trafficking of Membrane Proteins at Excitatory and Inhibitory Synapses

Scaffold Proteins in the Postsynaptic Density

Ca2+ Signaling in Dendritic Spines

Postsynaptic Targeting of Protein Kinases and Phosphatases

Long-Term Potentiation

Homeostatic Synaptic Plasticity

Ubiquitin and Protein Degradation in Synapse Function

Signaling from Synapse to Nucleus

Molecular Organization of the Postsynaptic Membrane at Inhibitory Synapses

Acid-Sensing Ion Channels (ASICs) and pH in Synapse Physiology

Glia as Active Participants in the Development and Function of Synapses

Plasticity of Dentate Granule Cell Mossy Fiber Synapses: A Putative Mechanism of Limbic Epileptogenesis

Stroke – A Synaptic Perspective

and Pathological Pain.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-51249-4

9786611512491

0-387-77232-4

OCLC:

272311384