Prion biology and diseases / edited by Stanley B. Prusiner.

Format:

Book

Contributor:

Prusiner, Stanley B., 1942-

Series:

Cold Spring Harbor monograph series.

Cold Spring Harbor monograph series

Language:

English

Subjects (All):

Prions.

Prion diseases.

Physical Description:

1 online resource (xiii, 794 pages) : illustrations (some color)

Place of Publication:

Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory Press, 1999.

Language Note:

English

Summary:

Provides an authoritative source on recent research in the study of prions, which are implicated in spongiform encephalopthies such as kuru and bovine encephalopathy. Early chapters provide an introduction to prion biology, record the development of the prion concept, describe bioassays for prions, explain basic principles of prion replication, and outline some methods for study of prions. Remaining chapters cover topics ranging from the cell biology of prions, to transgenic and gene-targeted mice, to inherited and infectious prion diseases of humans. Other subjects include fungal prions, biocontainment, and mammalian prion strains. The editor is associated with UC-San Francisco. Annotation copyrighted by Book News, Inc., Portland, OR

Contents:

1. An Introduction to Prion Biology and Diseases / S.B. Prusiner 2. Development of the Prion Concept / S.B. Prusiner 3. Bioassays of Prions / S.B. Prusiner, P. Tremblay and J. Safar / [and others] 4. Transmission and Replication of Prions / S.B. Prusiner, M.R. Scott and S.J. DeArmond / [and othe rs]5. Structural Studies of Prion Proteins / F.E. Cohen and S.B. PrusinerFungal Prions6. Prions of Fungi: [URE3], [PSI], and [Het-s] Discovered as Heritable Traits / R.B. Wickner and Y.O. ChernoffTransgenetics and Cell Biology of Prions7. Knockouts, Transgenics, and Transplants in Prion Research / C. Weissmann, A.J. Raeber and D. Shmerling / [et al.]8. Transgenetic Investigations of the Species Barrier and Prion Strains / M. Scott, S.J. DeArmond and S.B. Prusiner / [et al.]9. Cell Biology of Prions / S.B. Prusiner, P. Peters and K. Kaneko / [et al.]Prion Diseases in Animals10. Scrapie, Chronic Wasting Disease, and Transmissible Mink Encephalopathy / J.-L. Laplanche, N. Hunter and M. Shinagawa / [et al.]11. Bovine Spongiform Encephalopathy and Related Diseases / N. Nathanson, J. Wilesmith and G.A. Wells / [et al.]Human Prion Diseases12. Infectious and Sporadic Prion Diseases / R.G. Will, M.P. Alpers and D. Dormont / [et al.]13. Inherited Prion Diseases / P. Gambetti, R.B. Petersen and P. Parchi / [et al.]14. Neuropathology of Prion Diseases / S.J. DeArmond and J.W. IronsideMethodology and Future Studies15. Some Strategies and Methods for the Study of Prions / S.B. Prusiner, K. Kaneko and H. Serban / [et al.]16. Antibodies as Tools to Probe Prion Protein Biology / R.A. Williamson, D.R. Burton and D. Peretz / [et al.]17. Biosafety Issues in Prion Diseases / H. Baron, J. Safar and D. Groth / [et al.]

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references and index.

ISBN:

0-87969-656-7

OCLC:

614661641