Toxicity testing for assessment of environmental agents : interim report / Committee on Toxicity Testing and Assessment of Environmental Agents, Board on Environmental Studies and Toxicology, Institute for Laboratory Animal Research, Division on Earth and Life Studies, National Research Council of the National Academies.

Format:

Book

Contributor:

National Research Council (U.S.). Committee on Toxicity Testing and Assessment of Environmental Agents.

National Academies Press (U.S.)

Language:

English

Subjects (All):

Toxicity testing.

Toxicology.

Physical Description:

1 online resource (271 p.)

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academies Press, c2006.

Language Note:

English

Summary:

Toxicity testing in laboratory animals provides much of the information used by the Environmental Protection Agency (EPA) to assess the hazards and risks associated with exposure to environmental agents that might harm public health or the environment. The data are used to establish maximum acceptable concentrations of environmental agents in drinking water, set permissible limits of exposure of workers, define labeling requirements, establish tolerances for pesticides residues on food, and set other kinds of limits on the basis of risk assessment. Because the number of regulations that require toxicity testing is growing, EPA called for a comprehensive review of established and emerging toxicity-testing methods and strategies. This interim report reviews current toxicity-testing methods and strategies and near-term improvements in toxicity-testing approaches proposed by EPA and others. It identifies several recurring themes and questions in the various reports reviewed. The final report will present a long-range vision and strategic plan to advance the practices of toxicity testing and human health assessment of environmental contaminants.

Contents:

""Front matter""; ""Preface""; ""Abbreviations""; ""Contents""; ""Summary""; ""1 Introduction""; ""2 Animal and In Vitro Toxicity Testing""; ""3 Human Data""; ""4 Strategies for Toxicity Testing""; ""5 Use of Data in Human Health Risk Assessment""; ""6 New Approaches""; ""7 Alternative Approaches and Emerging Technologies""; ""Appendix A Biographic Information on the Committee on Toxicity Testing and Assessment of Environmental Agents""; ""Appendix B Testing Protocols""

Notes:

Description based upon print version of record.

Includes bibliographic references.

ISBN:

0-309-16486-9

1-280-44734-6

9786610447343

0-309-65652-4

OCLC:

923275379