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Validation of toxicogenomic technologies : a workshop summary / Committee on Validation of Toxicogenomic Technologies: a Focus on Chemical Classification Strategies ; Committee on Emerging Issues and Data on Environmental Contaminants, Board on Environmental Studies and Toxicology, Board on Life Studies, Division on Earth and Life Studies, National Research Council of the National Academies.
- Format:
- Book
- Author/Creator:
- National Research Council (U.S.). Committee on Validation of Toxicogenomic Technologies: A Focus on Chemical Classification Strategies.
- Language:
- English
- Subjects (All):
- Genetic toxicology--Congresses.
- Genetic toxicology.
- DNA microarrays--Statistical methods--Congresses.
- DNA microarrays.
- Physical Description:
- 1 online resource (98 p.)
- Edition:
- 1st ed.
- Place of Publication:
- Washington, D.C. : National Academies Press, c2007.
- Language Note:
- English
- Summary:
- Beginning in the early 1980s, new technologies, began to permit evaluation of the expression of individual genes. Recent technological advances have expanded those evaluations to permit the simultaneous detection of the expression of tens of thousands of genes and to support holistic evaluations of the entire genome. The application of these technologies has enabled researchers to unravel complexities of cell biology and, in conjunction with toxicologic evaluations, the technologies are used to probe and gain insight into questions of toxicologic relevance. As a result, the use of the technologies has become increasingly important for scientists in academia, as well as for the regulatory and drug development process.
- Contents:
- Experimental objectives of DNA microarray studies / Kevin K. Dobbin
- Comparison of microarray data from multiple labs and platforms / Rafael Irizarry
- Statistical analysis of toxicogenomic microarray data / Wherly Hoffman and Hui-Rong Qian
- Diagnostic classifier
- gaining confidence through validation / Weida Tong
- Appendixes : A. Workshop planning committee biographical information
- B. Workshop agenda
- C. Federal liaison group for the NRC Committee on Emerging Issues and data on environmental contaminants.
- Notes:
- Description based upon print version of record.
- Includes bibliographical references.
- ISBN:
- 0-309-17994-7
- 1-280-84479-5
- 9786610844791
- 0-309-66825-5
- OCLC:
- 923277813
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