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Insect cell cultures : fundamental and applied aspects / edited by J.M. Vlak ... [et al.].
- Format:
- Book
- Series:
- Current applications of cell culture engineering ; v. 2.
- Current applications in cell culture engineering ; vol. 2
- Language:
- English
- Subjects (All):
- Insect cell biotechnology.
- Insects--Viruses.
- Insects.
- Insects--Cytology.
- Physical Description:
- 1 online resource (325 p.)
- Edition:
- 1st ed. 2002.
- Place of Publication:
- Dordrecht [Netherlands] ; Boston : Kluwer, c1996.
- Language Note:
- English
- Summary:
- A comprehensive reference work covering the key issues in insect cell cultures, this text includes 30 review papers on such topics as: cell lines (development, characterisation, physiology, cultivation and medium design); viruses (virus-cell interactions, replication, recombinant construction, infection kinetics, post-translational modification and passage effects); engineering (shear, bioreactors including perfusion, immobilisation, scale-up and modelling, downstream processing); applications; and economics and regulatory aspects.; This text should be useful for cell biologists, biochemists, molecular biologists, virologists, immunologists and other basic and applied disciplines related to cell culture engineering, both academic and industrial.
- Contents:
- Insect Cell Lines
- Development and characterization of insect cell lines
- New approaches to insect tissue culture
- Transgenic insect cells: mosquito cell mutants and the dihydrofolate reductase gene
- Insect cell physiology
- Insect cell cultivation: growth and kinetics
- Medium design for insect cell culture
- Viruses
- Baculovirus-insect cell interactions
- Replication patterns and cytopathology of cells infected with baculoviruses
- Construction of baculovirus recombinants
- Passage effect of virus infection in insect cells
- Post-translational modifications in insect cells
- Productivity of insect cells for recombinant proteins
- Chaperone and foldase coexpression in the baculovirus-insect cell expression system
- Engineering Aspects
- Shear sensitivity of insect cells
- Insect cell bioreactors
- Perfusion bioreactors for the production of recombinant proteins in insect cells
- Immobilization of insect cells
- Modelling baculovirus infection of insect cells in culture
- Scale up aspects of sparged insect-cell bioreactors
- Oxygen gradients in small and big sparged insect-cell bioreactors
- Downstream processing of insect cell cultures
- Applications
- Parvovirus diagnostics and vaccine production in insect cells
- Classical swine fever virus diagnostics and vaccine production in insect cells
- Production of multidomain complement glycoproteins in insect cells
- Economic and Regulatory Aspects
- Economics of baculovirus-insect cell production systems
- Safety aspects of insect cell culture
- Regulatory issues in the use of insect-cell culture.
- Notes:
- Description based upon print version of record.
- Includes bibliographical references and index.
- ISBN:
- 1-280-04313-X
- 9786610043132
- 0-306-46850-6
- OCLC:
- 923696399
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