The practical bioinformatician / editor, Limsoon Wong.

Format:

Book

Contributor:

Wong, Limsoon, 1965-

Language:

English

Subjects (All):

Computational biology.

Bioinformatics.

Physical Description:

xxii, 517 p. : ill. (some col.), ports.

Edition:

1st ed.

Place of Publication:

River Edge, N.J. ; London : World Scientific, c2004.

Language Note:

English

Summary:

Computer scientists have increasingly been enlisted as "bioinformaticians" to assist molecular biologists in their research. This book is a practical introduction to bioinformatics for these computer scientists. The chapters are in-depth discussions by expert bioinformaticians on both general techniques and specific approaches to a range of selected bioinformatics problems. The book is organized into clusters of chapters on the following topics: - Overview of modern molecular biology and a broad spectrum of techniques from computer science -- data mining, machine learning, mathematical modeling, sequence alignment, data integration, workflow development, etc. - In-depth discussion of computational recognition of functional and regulatory sites in DNA sequences. - Incisive discussion of computational prediction of secondary structure of RNA sequences. - Overview of computational prediction of protein cellular localization, and selected discussions of inference of protein function. - Overview of methods for discovering protein-protein interactions. - Detailed discussion of approaches to gene expression analysis for the diagnosis of diseases, the treatment of diseases, and the understanding of gene functions. - Case studies on analysis of phylogenies, functional annotation of proteins, construction of purpose-built integrated biological databases, and development of workflows underlying the large-scale-effort gene discovery.

Contents:

Chapter 1. Molecular Biology for the Practical Bioinformatician

Chapter 2. Strategy and Planning of Bioinformatics Experiments

Chapter 3. DataMining Techniques for the Practical Bioinformatician

Chapter 4. Techniques for Recognition of Translation Initiation Sites

Chapter 5. How Neural Networks Find Promoters Using Recognition of Micro-Structural Promoter Components

Chapter 6. Neural-StatisticalModel of TATA-Box Motifs in Eukaryotes

Chapter 7. Tuning the Dragon Promoter Finder System for Human Promoter Recognition

Chapter 8. RNA Secondary Structure Prediction

Chapter 9. Protein Localization Prediction

Chapter 10. Homology Search Methods

Chapter 11. Analysis of Phylogeny: A Case Study on Saururaceae

Chapter 12. Functional Annotation and Protein Families: From Theory to Practice

Chapter 13. Discovering Protein-Protein Interactions

Chapter 14. Techniques for Analysis of Gene Expression

Chapter 15. Genome-Wide cDNA Oligo Probe Design and its Applications in Schizosaccharomyces Pombe

Chapter 16. Mining New Motifs from cDNA Sequence Data

Chapter 17. Technologies for Biological Data Integration

Chapter 18. Construction of Biological Databases: A Case Study on the Protein Phosphatase DataBase (PPDB)

Chapter 19. A Family Classification Approach to Functional Annotation of Proteins

Chapter 20. Informatics for Efficient EST-Based Gene Discovery in Normalized and Subtracted cDNA Libraries.

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references (p. 457-509).

ISBN:

9786611872311

9781281872319

1281872318

9789812562340

9812562346

OCLC:

815742847