Cellular peptidases in immune functions and diseases 2 / edited by Jurgen Langner and Siegfried Ansorge.

Format:

Book

Conference/Event

Contributor:

Langner, Jürgen.

Ansorge, Siegfried.

Conference Name:

International Conference on Cellular Peptidases in Immune Functions and Diseases (2nd : 1999 : Magdeburg, Germany)

Series:

Advances in experimental medicine and biology ; v. 477.

Advances in experimental medicine and biology, 0065-2598 ; v. 477

Language:

English

Subjects (All):

Peptidase--Immunology--Congresses.

Peptidase.

Peptidase--Pathophysiology--Congresses.

Endopeptidases--Immunology--Congresses.

Endopeptidases.

Endopeptidases--Pathophysiology--Congresses.

Physical Description:

1 online resource (537 p.)

Edition:

1st ed. 2002.

Place of Publication:

New York : Kluwer Academic/Plenum, c2000.

Language Note:

English

Summary:

Of the many special roles played by proteolytic enzymes in immune reactions, this study addresses different aspects of membrane peptidases, signal transduction via ligation of membrane peptidases (especially of dipeptidyl peptidase IV/CD26 and aminopeptidase N/CD13), and regulation of membrane peptidases in vivo and in vitro. A number of newly discovered peptidases (including cathepsin F, W and X, carboxypeptidase X, attractin) are described, with special emphasis given to the role of peptidases in immune and defense reactions and in the pathogenesis of inflammatory and other diseases, including rheumatoid arthritis, pancreatitis, multiple sclerosis, Alzheimer's disease and tumours of various origins. The focus on the involvement of a selection of proteolytic enzymes in immune reactions and diseases is a useful feature of this multifaceted work, which combines biochemical, immunological and clinical research reports with literary reviews of the field.

Contents:

Membrane Ectopeptidases with Influence on Immune Functions

Review: The Role of Membrane Peptidase in Immune Functions

Structure and Function of Aminopeptidase N

Modulation of WNT-5At Eexpression by Actinonin: Linkage of APN to the WNT-Pathway?

Enzymatic Activity Is Not A Precondition For The Intracellular Calcium Increase Mediated By mAbs Specific For Aminopeptidase N/CD13

Transforming Growth Factor-? Increases the Expression of Aminopeptidase N/CD13 mRNA and Protein in Monocytes and Monocytic Cell Lines

Cell-Cell Contact Between Lymphocytes and Fibroblast-Like Synovioctyes Induces Lymphocytic Expression of Aminopeptidase n/cd13 and Results in Lymphocytic Activation

Natural Substrates of Dipeptidyl Peptidase IV

Relating Structure to Function in the Beta-Propeller Domain of Dipeptidyl Peptidase IV

Development of a Tertiary-Structure Model of the C-Terminal Domain of DPP IV

Post Proline Cleaving Peptidases Having DP IV Like Enzyme Activity

A New Type of Fluorogenic Substrates for Determination of Cellular Dipeptidyl Peptidese IV (DP IV/CD26) Activity

Potent Inhibitors of Dipeptidyl Peptidase iv and Their Mechanisms of Inhibition

N-Terminal HIV-1 Tat Nonapeptides as Inhibitors of Dipeptidyl Peptidase IV. Conformational Characterization

Signal Transduction Events Induced or Affected by Inhibition of the Catalytic Activity of Dipeptidyl Peptidase IV (DP IV, CD26)

Specific Inhibitors of Dipeptidyl Peptidase IV Suppress mRNA Expression of DP IV/CD26 and Cytokines

Dipeptidyl Peptidase IV in Inflammatory CNS Disease

Dipeptidyl Peptidase IV (CD26): Role in T Cell Activation and Autoimmune Disease

Effects of Nonapeptides Derived From the N-terminal Structure of Human Immunodeficiency Virus-1 (HIV-1) Tat on Suppression of CD26-Dependent T Cell Growth

DNA Synthesis in Cultured Human Keratinocytes and Hacat Kerationcytes is Reduced by Specific Inhibition of Dipeptidyl Peptidase IV (CD26) Enzymatic Activity

Attractin: A Cub-Family Protease Involved in T Cell-Monocyte/Macrophage Interactions

Analogs of Glucose-Dependent Insulinotropic Polypeptide With Increased Dipeptidyl Peptidase IV Resistance

Dipeptidyl Peptidase IV (DPP IV, CD26) In Patients With Mental Eating Disorders

The Membrane-Bound Ectopeptidase CPM as a Marker Of Macrophage Maturation in vitro And in vivo

Matrix Metalloproteinases (MMP-8, -13 and -14) Interact with the Clotting System and Degrade Fibrinogen and Factor XII (Hagemann Factor)

The Neprilysin Family in Health and Disease

Cellular Endopeptidases: New Cathepsins; Results from Knock-out-mice; Regulatory Aspects

Review: Novel Cysteine Proteases of the Papain Family

Development and Validation of Homology Models of Human Cathepsins K, S, H, and F

The Function of Propeptide Domains of Cysteine Proteinases

Human Cathepsins W and F form A New Subgroup of Cathepsins that is Evolutionary Separated from the Cathepsin B- and L-Like Cysteine Proteases

Cathepsin K Expression in Human Lung

Expression of Cathepsins B and L in Human Lung Epithelial Cells is Regulated by Cytokines

Functions of Cathepsin K in Bone Resorption

Ceramide as an Activator Lipid of Cathepsin D

Human Cathepsin X

A Novel Proteolytic Mechanism for Termination of the Ca2+ Signalling Evoked by Proteinase-Activated Receptor-1 (PAR-1) in Rat Astrocytes

Natural and Synthetic Inhibitors of The Tumor-Associated Serine Protease Urokinase-Type Plasminogen Activator

Processing of Interleukin-18 by Human Vascular Smooth Muscle Cells

Peptidases and Peptidase Inhibitors in Pathogensis of Diseases

Review: Peptidases and Peptidase Inhibitors in the Pathogenesis of Diseases

The Role of Proteolysis in Alzheimer’s Disease

Observing Proteases in Living Cells

The Role of Cysteine Proteases in Intracellular Pancreatic Serine Protease Activation

Peptidases in the Asthmatic Airways

Inactivation of Interleukin-6 by Neutrophil Proteases at Sites of Inflammation

Antisense Inhibition of Cathepsin Bina Human Osteosarcoma Cell Line

Protease-Protease Inhibitor Balance in the Gastric Mucosa

The Role of Bacterial and Host Proteinases in Periodontal Disease

Multifunctional Role of Proteases in Rhumatic Diseases

Evidence of Proteolytic Activation of Transforming Growth Factor ? in Synovial Fluid

Matrix Metalloproteinases and Tace Play A Role in The Pathogenesis of Endometriosis

Influence of Proliferation, Differentiation and Dedifferentiation Factors on the Expression of the Lysosomal Cysteine Proteinase Cathepsin L (CL) in Thyroid Cancer Cell Lines.

Notes:

"Proceedings of an International Conference on Cellular Peptidases in Immune Functions and Diseases (II), held September 12-14, 1999, in Magdeburg, Germany"--T.p. verso.

Includes bibliographical references and index.

ISBN:

1-280-04290-7

9786610042906

0-306-46826-3

OCLC:

923696668