Computational biology of cancer : lecture notes and mathematical modeling / Dominik Wodarz and Natalia Komarova.

Format:

Book

Author/Creator:

Wodarz, Dominik.

Contributor:

Komarova, Natalia L.

Language:

English

Subjects (All):

Cancer--Mathematical models.

Cancer.

Cancer--Research.

Physical Description:

1 online resource (266 p.)

Edition:

1st ed.

Place of Publication:

Hackensack, NJ : World Scientific, 2005.

Language Note:

English

Summary:

The book shows how mathematical and computational models can be used to study cancer biology. It introduces the concept of mathematical modeling and then applies it to a variety of topics in cancer biology. These include aspects of cancer initiation and progression, such as the somatic evolution of cells, genetic instability, and angiogenesis. The book also discusses the use of mathematical models for the analysis of therapeutic approaches such as chemotherapy, immunotherapy, and the use of oncolytic viruses.

Contents:

Preface; Contents; Chapter 1 Cancer and somatic evolution; Chapter 2 Mathematical modeling of tumorigenesis; Chapter 3 Cancer initiation: one-hit and two-hit stochastic models; Chapter 4 Microsatellite and chromosomal instability in sporadic and familial cancers; Chapter 5 Cellular origins of cancer; Chapter 6 Costs and benefits of chromosomal instability; Chapter 7 DNA damage and genetic instability; Chapter 8 Tissue aging and the development of cancer; Chapter 9 Basic models of tumor inhibition and promotion; Chapter 10 Mechanisms of tumor neovascularization

Chapter 11 Cancer and immune responsesChapter 12 Therapeutic approaches: viruses as anti-tumor weapons; Appendix A Exact formula for total probability of double mutations; Bibliography; Index

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786611897086

9781281897084

1281897086

9789812701367

9812701362

OCLC:

476063316