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Conformational proteomics of macromolecular architecture : approaching the structure of large molecular assemblies and their mechanisms of action / R. Holland Cheng & Lena Hammar, editors.
- Format:
- Book
- Language:
- English
- Subjects (All):
- Molecular structure.
- Macromolecules.
- Physical Description:
- 1 online resource (433 p.)
- Edition:
- 1st ed.
- Place of Publication:
- New Jersey ; London : World Scientific Publishing, 2004.
- Language Note:
- English
- Summary:
- Biological processes involving large macromolecular assemblies arethought to be a dynamic consequence of cooperativity andmetastability. The folding of a peptide chain creates localenvironments from which ""activity"" can emerge. In the same way, theassembly of large molecular complexes creates dynamic features thatwould only be feasible in a large construct. The biologicalimplications of such adaptation will be explored as it applies to thestatic quasisymmetry situations, as well as to the dynamics ofstructural transitions. The current wealth of solved high-resolutioncomplex structures makes
- Contents:
- Conformational Proteomics of Macromolecular Architecture: Approaching the Structure of Large Molecular Assemblies and Their Mechanisms of Action; PREFACE; Dynamic Architectures; The Theory of Quasi-equivalence; Approaching Large Assemblies in Membranes; Protein Shuttle; Molecular Machines; Conformational Proteomics; Acknowledgements; CONTENTS; Chapter 1. Early Theories of Virus Structure; Chapter 2. Quasi-Equivalence and Adaptability in Living Molecular Assemblies; Chapter 3. The Role of Disordered Segments in Viral Coat Proteins
- Chapter 4. Prefusion Dynamics in an Enveloped Virus - Alphavirus ModelChapter 5. Strategy to Obtain High Resolution Structure of Membrane Proteins by X-ray Crystallography; Chapter 6. On the Possibility of Determining Structures of Membrane Proteins in Two-Dimensional Crystals; Chapter 7. Functional Details on Membrane Proteins Observed Through an Electron Beam; Chapter 8. Clathrin and Companions; Chapter 9. Multifunctional Enzyme Complexes: Multistep Catalysis by Molecular Machines; Chapter 10. Metamorphosis of an Enzyme
- Chapter 11. Optimizing an Enzyme for Its Physiological Role: Structural and Functional Comparisons of ATP Sulfurylases from Three Different OrganismsChapter 12. Ribosomal Crystallography: Dynamics, Flexibility and Peptide Bond Formation; Chapter 13. The Dynamics of the Ribosome as Inferred by Cryo-EM: Induced and Self-Organized Motions; Chapter 14. How do Translation Factors Catalyze Protein Synthesis; Chapter 15 . Dynamic Aspects of the Bacterial Flagellum; Chapter 16. Myosin Polymorphism and Muscle Contraction
- Chapter 17. Is Crystallization a ""Bottleneck"" of Modern Structural Crystallomic?Chapter 18. Sensor Surface Interactions in the Study of Macromolecular Assemblies; Chapter 19. PPiDB - A Protein-Protein Interactions Database; Chapter 20. Virus Particle Explorer (VIPER): A Repository of Virus Capsid Structures; Index
- Notes:
- Description based upon print version of record.
- Includes bibliographical references and index.
- ISBN:
- 9786611347697
- 9781281347695
- 1281347698
- 9789812562647
- 9812562648
- OCLC:
- 475937245
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