Gene expression profiling by microarrays : clinical implications / edited by Wolf-Karsten Hofmann.

Format:

Book

Contributor:

Hofmann, Wolf-Karsten, editor.

Language:

English

Subjects (All):

Gene expression.

Medical genetics.

Physical Description:

1 online resource (xiv, 246 pages) : digital, PDF file(s).

Edition:

1st ed.

Place of Publication:

Cambridge : Cambridge University Press, 2006.

Language Note:

English

Summary:

Microarray analysis is a highly efficient tool for assessing the expression of a large number of genes simultaneously, and offers a new means to classify cancer and other diseases. Gene expression profiling can also be used to predict clinical outcome and response to specific therapeutic agents. This survey spans recent applications of microarrays in clinical medicine, covering malignant disease including acute leukaemias, lymphoid malignancies and breast cancer, together with diabetes and heart disease. Investigators in oncology, pharmacology and related clinical sciences, as well as basic scientists, will value this review of a promising new diagnostic and prognostic technology.

Contents:

Technique of microarrays : microarray platforms / Sven de Vos

Quantitative quality control of microarray experiments : toward accurate gene expression measurements / Xujing Wang and Martin J. Hessner

Statistical analysis of gene expression data / David A. Elashoff

Genomic stratification in patients with heart failure / Tara A. Bullard [and others]

Gene expression profiling for the diagnosis of acute leukemias / Torsten Haferlach [and others]

Gene expression profiling can distinguish tumor subclasses of breast carcinomas / Ingrid A. Hedenfalk

Gene expression profiling in lymphoid malignancies / Christof Burek [and others]

mRNA profiling of pancreatic beta-cells : investigating mechanisms of diabetes / Leentje Van Lommel [and others]

Prediction of response and resistance to treatment by gene expression profiling / Philipp Kiewe and Wolf-Karsten Hofmann.

Notes:

Title from publisher's bibliographic system (viewed on 05 Oct 2015).

Includes bibliographical references and index.

ISBN:

1-107-16571-7

1-280-48040-8

9786610480401

0-511-22081-2

0-511-22122-3

0-511-21925-3

0-511-31717-4

0-511-54584-3

0-511-21993-8

OCLC:

173610036

Publisher Number:

9780521853965