Principles of regenerative medicine / Anthony Atala ... [et al.], [eds.].

Format:

Book

Contributor:

Atala, Anthony, 1958-

Language:

English

Subjects (All):

Regeneration (Biology).

Growth.

Physical Description:

1 online resource (1473 p.)

Edition:

1st ed.

Place of Publication:

Burlington, MA : Academic Press, c2008.

Language Note:

English

Summary:

Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure.* Key for all researc

Contents:

Front Cover; Principles of Regenerative Medicine; Copyright Page; Contents; Preface; List of Contributors; Part I: Introduction to Regenerative Medicine; Chapter 1. Current and Future Perspectives of Regenerative Medicine; REGENERATIVE MEDICINE: CURRENT AND FUTURE PERSPECTIVES; CONCLUSIONS; REFERENCES; Chapter 2. Fundamentals of Cell-Based Therapies; INTRODUCTION; RATIONALE FOR CELL-BASED THERAPIES; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; Chapter 3. Stem Cell Research; INTRODUCTION; STEM CELLS; STEM CELL MODULATION IN VITRO; REGENERATIVE MEDICINE; CONCLUSION; ACKNOWLEDGMENTS

INTERNET RESOURCESREFERENCES; Part II: Biologic and Molecular Basis of Regenerative Medicine; Chapter 4. Molecular Organization of Cells; INTRODUCTION; CELLULAR MECHANISMS OF THE EMT; MOLECULAR CONTROL OF THE EMT; CONCLUSION; REFERENCES; Chapter 5. Cell-ECM Interactions in Repair and Regeneration; INTRODUCTION; COMPOSITION AND DIVERSITY OF THE ECM; RECEPTORS FOR ECM MOLECULES; SIGNAL TRANSDUCTION EVENTS DURING CELL-ECM INTERACTIONS; CELL-ECM INTERACTIONS DURING HEALING OF SKIN WOUNDS; CELL-ECM INTERACTIONS DURING REGENERATION; IMPLICATIONS FOR REGENERATIVE MEDICINE; REFERENCES

Chapter 6. Developmental Mechanisms of RegenerationINTRODUCTION; MECHANISMS OF REGENERATION; STRATEGIES OF REGENERATIVE MEDICINE; CONCLUSION; ACKNOWLEDGMENT; REFERENCES; Chapter 7. The Molecular Basis of Pluripotency in Principles of Regenerative Medicine; INTRODUCTION TO PLURIPOTENCY; EXTRACELLULAR SIGNALING FACTORS AND SIGNAL TRANSDUCTION; TRANSCRIPTIONAL NETWORKS; EPIGENETIC AND ENVIRONMENTAL REGULATION; SUMMARY AND PERSPECTIVES; REFERENCES; Chapter 8. How Do Cells Change Their Phenotype; INTRODUCTION; STEM CELLS; PLASTICITY - TRANSDIFFERENTIATION AND TRANSDETERMINATION; CELL FUSION

CELL PHENOTYPECONTROL OF GENE ACTIVITY; EXTRINSIC CONTROLS; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; Chapter 9. Somatic Cloning and Epigenetic Reprogramming in Mammals; INTRODUCTION: SHORT HISTORY OF CLONING; TECHNICAL ASPECTS OF SOMATIC NT; SUCCESS RATES OF SOMATIC CLONING AND THE QUESTION OF NORMALITY OF CLONED OFFSPRING; EPIGENETIC REPROGRAMMING; APPLICATION OF SOMATIC NT; CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; Chapter 10. Transgenic Cloned Goats and Cows for the Production of Therapeutic Proteins; INTRODUCTION; GENERATION OF TRANSGENIC ANIMALS

SCNT: DONOR CELL LINE DEVELOPMENT AND CHARACTERIZATIONCAPRINE SCNT; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES; Part III: Cells and Tissue Development; Chapter 11. Genetic Approaches in Human Embryonic Stem Cells and Their Derivatives; INTRODUCTION; MAINTAINING UNDIFFERENTIATED HESCS; GENETIC APPROACHES TO MANIPULATING HESCS; DIFFERENTIATION OF HESCS INTO TISSUE-SPECIFIC LINEAGES AND TRANSPLANTATION OF HESC-DERIVED CELLS; GENETIC MODIFICATIONS OF HESC-DERIVED PROGENIES; POTENTIAL APPLICATIONS OF GENETICALLY MANIPULATED HESCS AND THEIR DERIVATIVES; CONCLUSION; ACKNOWLEDGMENT; REFERENCES

Chapter 12. Embryonic Stem Cells: Derivation and Properties

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-09613-X

9786611096137

0-08-055595-0

OCLC:

476125492