Protein trafficking in neurons / editor, Andrew Bean.

Format:

Book

Contributor:

Bean, Andrew J.

Language:

English

Subjects (All):

Proteins--Physiological transport.

Proteins.

Neurons.

Physical Description:

1 online resource (466 p.)

Edition:

1st ed.

Place of Publication:

Amsterdam ; Boston : Elsevier/Academic Press, c2007.

Language Note:

English

Summary:

The efficient delivery of cellular constituents to their proper location is of fundamental importance for all cells and is of particular interest to neuroscientists, because of the unique functions and complex architecture of neurons. Protein Trafficking in Neurons examines mechanisms of protein trafficking and the role of trafficking in neuronal functioning from development to plasticity to disease. The book is divided into seven sections that review mechanisms of protein transport, the role of protein trafficking in synapse formation, exo- and endocytosis, transport of receptors, tra

Contents:

Front cover; Title page; Copyright page; Table of contents; Contributors; Acknowledgments; SECTION I: PROTEIN MOVEMENT; CHAPTER 1: Molecular Mobility in Cells Examined with Optical Methods; I. BROWNIAN MOTION AND THE FUNDAMENTALS OF DIFFUSION; II. A VIEW OF CYTOPLASM AND MEMBRANE FROM THE SINGLE MOLECULE PERSPECTIVE; III. DIFFUSION AND MOBILITY OF PROTEINS IN CELLS STUDIED WITH BIOPHYSICAL TECHNIQUES; IV. CONCLUSIONS AND FUTURE DIRECTIONS; CHAPTER 2: The Role of Molecular Motors in Axonal Transport; I. INTRODUCTION; II. KINESIN; III. CYTOPLASMIC DYNEIN; IV. DYNACTIN; V. MYOSIN

VI. TRANSPORT REGULATION AND CONTROLVII. AXONAL TRANSPORT; VIII. PROTEIN DEGRADATION; IX. mRNA LOCALIZATION; X. MITOCHONDRIA TRANSPORT; XI. AXON SIGNALING STRATEGY; XII. SIGNALING ADAPTORS; XIII. SURVIVAL SIGNALING; XIV. DEATH SIGNALS; XV. VIRUSES; XVI. NEURODEGENERATIVE DISEASE; XVII. SUMMARY; References; CHAPTER 3: Role of APC Complexes and the Microtubule Cytoskeleton in Neuronal Morphogenesis; I. INTRODUCTION; II. ROLE OF MICROTUBULES IN NEURONAL POLARIZATION; III. TARGETING OF APC TO TIPS OF NEURITES; IV. ROLE OF APC IN MICROTUBULE DYNAMICS AT TIPS OF NEURITES; V. SUMMARY; References

SECTION II: SYNAPTIC DEVELOPMENTCHAPTER 4: Assembly of Synapses in the Vertebrate Central Nervous System; I. INTRODUCTION; II. CELL BIOLOGY OF CNS SYNAPSES; III. MOLECULAR MECHANISMS OF SYNAPSE FORMATION; IV. SYNAPTIC SPECIFICITY AND MOLECULAR DIVERSITY OF CELL SURFACE RECEPTORS; V. CONCLUDING REMARKS; References; CHAPTER 5: Presynaptic Terminal Differentiation; I. MORPHOLOGY OF THE PRESYNAPTIC TERMINI OF VERTEBRATE AND INVERTEBRATE SYNAPSES; II. PROTEIN COMPONENTS OF PRESYNAPTIC TERMINI; III. SNAREs; IV. FUTURE PERSPECTIVES; References; SECTION III: EXO-/ENDOCYTOSIS

CHAPTER 6: Neuronal ExocytosisI. INTRODUCTION; II. CONCLUSIONS; References; CHAPTER 7: Endocytosis in Neurons; I. ENDOCYTOSIS IN NEURONS; II. THE CLATHRIN-DEPENDENT ENDOCYTIC MACHINERY; III. MECHANISMS OF PRESYNAPTIC VESICLE CYCLING; IV. ENDOCYTOSIS OF POSTSYNAPTIC NEUROTRANSMITTER RECEPTORS; V. CONCLUSIONS; References; SECTION IV: RECEPTOR TRAFFICKING; CHAPTER 8: Postsynaptic Machinery for Receptor Trafficking; I. POSTSYNAPTIC MICROANATOMY: DENDRITES AND SPINES; II. TRAFFICKING OF NEW RECEPTORS: DENDRITIC SECRETORY ORGANELLES; III. ENDOCYTOSIS AND THE ENDOCYTIC ZONE

IV. ENDOSOMES AND RECEPTOR RECYCLINGV. THE EXTRASYNAPTIC PLASMA MEMBRANE AND LATERAL MOVEMENT OF RECEPTORS; VI. PERSPECTIVES; References; CHAPTER 9: Synaptic Trafficking of AMPA Receptors; I. INTRODUCTION; II. REGULATED RECEPTOR ASSEMBLY AND EXIT FROM THE ER; III. DENDRITIC LOCALIZATION AND MEMBRANE INSERTION; IV. RETENTION AND CONSTITUTIVE CYCLING AT THE SYNAPSE; V. REGULATED SYNAPTIC TARGETING; VI. CONCLUSIONS; References; CHAPTER 10: Subunit-Specific NMDA Receptor Trafficking to Synapses; I. INTRODUCTION; II. ASSEMBLY OF NMDA-Rs

III. EXITING THE ENDOPLASMIC RETICULUM-THE ROLE OF NR1 SUBUNIT

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-280-70761-5

9786610707614

0-08-046589-7

OCLC:

437175603