Principles of nucleic acid structure / Stephen Neidle.

Format:

Book

Author/Creator:

Neidle, Stephen.

Language:

English

Subjects (All):

Nucleic acids.

Biomolecules.

Physical Description:

1 online resource (302 p.)

Edition:

1st ed.

Place of Publication:

Amsterdam : Elsevier ; Boston : Academic Press, 2008.

Language Note:

English

Summary:

This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, the book includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest

Contents:

Front Cover; Principles of Nucleic Acid Structure; Copyright Page; Dedication Page; Preface; Contents; Chapter 1: Methods for Studying Nucleic Acid Structure; 1.1 Introduction; 1.2 X-ray Diffraction Methods for Structural Analysis; 1.2.1 Overview; 1.2.2 Fiber Diffraction Methods; 1.2.3 Single-Crystal Methods; 1.3 NMR Methods for Studying Nucleic Acid Structure and Dynamics; 1.4 Molecular Modelling and Simulation of Nucleic Acids; 1.5 Chemical, Enzymatic, and Biophysical Probes of Structure and Dynamics; 1.6 Sources of Structural Data; 1.7 Visualization of Nucleic Acid Molecular Structures

1.7.1 The Structures in This Book References; Further Reading; Chapter 2: The Building-Blocks of DNA and RNA; 2.1 Introduction; 2.2 Base Pairing; 2.3 Base and Base Pair Flexibility; 2.4 Sugar Puckers; 2.5 Conformations About the Glycosidic Bond; 2.6 The Backbone Torsion Angles and Correlated Flexibility; References; Further Reading; Chapter 3: DNA Structure as Observed in Fibers and Crystals; 3.1 Structural Fundamentals; 3.1.1 Helical Parameters; 3.1.2 Base-Pair Morphological Features; 3.2 Polynucleotide Structures from Fiber Diffraction Studies; 3.2.1 Classic DNA Structures

3.2.2 DNA Polymorphism in Fibers 3.3 B-DNA Oligonucleotide Structure as Seen in Crystallographic Analyses; 3.3.1 The Dickerson-Drew Dodecamer; 3.3.2 Other Studies of the Dickerson-Drew Dodecamer; 3.3.3 Other B-DNA Oligonucleotide Structures; 3.3.4 Sequence-Dependent Features of B-DNA: Their Occurrence and Their Prediction; 3.4 A-DNA Oligonucleotide Crystal Structures; 3.4.1 A-Form Octanucleotides; 3.4.2 Do A-Form Oligonucleotides Occur in Solution? Crystal-Packing Effects; 3.4.3 The A harr B Transition in Crystals; 3.5 Z-DNA - Left-Handed DNA; 3.5.1 The Z-DNA Hexanucleotide Crystal Structure

3.5.2 Overall Structural Features3.5.3 The Z-DNA Helix; 3.5.4 Other Z-DNA Structures; 3.5.5 Biological Aspects of Z-DNA; 3.6 Bent DNA; 3.6.1 DNA Periodicity in Solution; 3.6.2 A-Tracts and Bending; 3.6.3 Structures Showing Bending; 3.6.4 The Structure of Poly dAmiddotdT; 3.7 Concluding Remarks; References; Further Reading; Chapter 4: Nonstandard and Higher-Order DNA Structures: DNA-DNA Recognition; 4.1 Mismatches in DNA; 4.1.1 General Features; 4.1.2 Purine:Purine Mismatches; 4.1.3 Alkylation Mismatches; 4.2 DNA Triple Helices; 4.2.1 Introduction; 4.2.2 Structural Studies

4.2.3 Antiparallel Triplexes and Nonstandard Base-pairings 4.2.4 Triplex Applications; 4.3 Guanine Quadruplexes; 4.3.1 Introduction; 4.3.2 Overall Structural Features of Quadruplex DNA; 4.3.3 Examples of Simple Quadruplex Structures; 4.3.4 Some Complex Quadruplex Structures; 4.3.5 The i-Motif; 4.4 DNA Junctions; 4.4.1 Holliday Junction Structures; 4.4.2 DNA Enzyme Structures; 4.5 Unnatural DNA Structures; References; Further Reading; Chapter 5: Principles of Small Molecule-DNA Recognition; 5.1 Introduction; 5.2 DNA-Water Interactions; 5.2.1 Hydration in the Grooves in Detail

5.3 General Features of DNA-Drug and Small-Molecule Recognition

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-281-05937-4

9786611059378

0-08-055352-4

OCLC:

437191722