Foundations of comparative genomics / Arcady R. Mushegian.

Format:

Book

Author/Creator:

Mushegian, Arcady R.

Language:

English

Subjects (All):

Genomics.

Gene mapping.

Physiology, Comparative.

Physical Description:

1 online resource (276 p.)

Edition:

1st ed.

Place of Publication:

Amsterdam ; Boston : Academic Press, c2007.

Language Note:

English

Summary:

This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as

Contents:

The beginning of computational genomics

Finding sequence similarities

Homology: can we get it right?

Getting ready for the era of comparative genomics: the importance of viruses

The first fact of comparative genomics: protein sequences are remarkably resilient in evolution

The second fact of comparative genomics: functional convergence at the molecular level

Prediction of function and reconstruction of metabolism from genomic data: homology-based approaches

Prediction of function and reconstruction of metabolism: post-homology approaches

Structural genomics: what does it tell us about life?

How many protein families are there?

Phylogenetic inference and the era of complete genomes

Two stories about evolution

Minimal and ancestral genomes

Comparative genomics and systems biology.

Notes:

Description based upon print version of record.

Includes bibliographical references (p. 238-257) and index.

ISBN:

1-281-03696-X

9786611036966

0-08-054609-9

OCLC:

476077150