Landmark papers in clinical chemistry / edited by Richard M. Rocco.

Format:

Book

Contributor:

Rocco, Richard M.

Language:

English

Subjects (All):

Clinical chemistry.

Biochemistry.

Physical Description:

1 online resource (xvii, 504 pages) : illustrations

Edition:

1st ed.

Place of Publication:

Amsterdam : Elsevier, 2006.

Language Note:

English

Summary:

This is the first major review of the developments in clinical laboratory science in the 20th century presented in the words of the original inventors and discoverers. Introductory comments by the editor help place the works within the historical context. Landmark Papers addresses:*The origin of the home pregnancy test available today in every drugstore*The woman who invented a billion dollar technology, refused to patent it and went on to win a Nobel Prize*The scientists who worked on the US Government's crash program at the start of WWII to find a substitute for the malaria drug quinine.

Contents:

Front Cover; Landmark Papers in Clinical Chemistry; Copyright Page; Contents; Foreword; Introduction; Acknowledgments; Claude Bernard; Section I: Immunoassay Technology; RIA (Radioimmunoassay); 1.Immunoassay of endogenous plasma insulin in man. Commentary; Landmark Paper; FPIA (Fluorescence Polarization Immunoassay); 2. Quantification of the antigen-antibody reaction by the polarization of fluorescence. Commentary; Landmark Paper; CPB (Competitive Protein Binding); 3. Determination of thyroxine utilizing the property of protein-binding. Commentary; Landmark Paper

ELISA (Enzyme-Linked Immunosorbent Assay); 4. Enzyme-linked immunosorbent assay II. Commentary; Landmark Paper; EMITTM (Enzyme Immunoassay Technique); 5. ""Homogeneous"" enzyme immunoassay. A new immunochemical technique. Commentary; Landmark Paper; Section II: Therapeutic Drug Monitoring (TDM); Bromide; 6. Rational bromide treatment. New methods for its control. Commentary; Landmark Paper; Sulfanilamide; 7. A new coupling component for sulfanilamide determination. Commentary; Landmark Paper; Quinacrine; 8. The estimation of Atabrine in biological fluids and tissues. Commentary; Landmark Paper

Digoxin9. Determination of therapeutic and toxic serum digoxin concentrations by radioimmunoassay. Commentary; Landmark Paper; Theophylline; 10. Determination of theophylline and its metabolites in human urine and serum by high-pressure liquid chromatography. Commentary; Landmark Paper; Section III: Enzymology; ALP (Alkaline Phosphatase, EC 3.1.3.1); 11. A method for the rapid determination of alkaline phosphatase with five cubic millimeters of serum. Commentary; Landmark Paper; AST (Aspartate Aminotransferase, EC 2.6.1.1); 12. Transaminase activity in human blood. Commentary; Landmark Paper

CK (Creatine Kinase, EC 2.7.3.2); 13. Separation of tissue and serum creatine kinase isoenzymes by ion-exchange column chromatography. Commentary; Landmark Paper; Section IV: Specific Analytes; Colorimetric Analysis with the Duboscq; 14. A system of blood analysis. Commentary; Landmark Paper; Blood Gases by Manometer; 15. The determination of gases in blood and other solutions by vacuum extraction and manometric measurement. I. Commentary; Landmark Paper; Bilirubin With the Filter Photometer; 16. The determination of bilirubin with the photoelectric colorimeter. Commentary; Landmark Paper

Proteins by the Biuret Reaction; 17. Determination of serum proteins by means of the biuret reaction. Commentary; Landmark Paper; Methods for Pediatric and Neonatal Samples; 18. Routine use of ultramicro methods in the clinical laboratory. Commentary; Landmark Paper; Enzymatic Glucose; 19. Use of glucose oxidase, peroxidase, and o-dianisidine in determination of blood and urinary glucose. Commentary; Landmark Paper; HCG (Human Chorionic Gonadotropin) by Immunoassay; 20. An immunological pregnancy test. Commentary; Landmark Paper; Hemoglobin Alc; 21. An abnormal hemoglobin in red cells of diabetics. Commentary

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-280-63838-9

9786610638383

0-08-045894-7

OCLC:

476002061