Neuroscience for neurologists / edited by Patrick F. Chinnery.

Format:

Book

Contributor:

Chinnery, Patrick F.

Language:

English

Subjects (All):

Neurosciences.

Neurology.

Physical Description:

xviii, 448 p. : ill.

Edition:

1st ed.

Place of Publication:

London : Imperial College Press, c2006.

Language Note:

English

Summary:

"The last decade has seen major advances in our understanding of the basic scientific principles that underpin clinical neurology. Many of these advances have already had a major impact on routine clinical practice, and this is likely to continue in the future. Although this makes it an exciting time to practice neurology, it also presents new challenges. How can established general neurologists keep up-to-date with clinically relevant scientific advances, and how can the specialist remain competent outside his own field? What should trainee neurologists learn to prepare themselves for the future career? Written by experts in the field, this timely book presents the scientific principles behind neurology. It aims to take the reader from the human genome, through gene expression, to molecular and cellular pathology, and subsequently to contemporary clinical investigations and clinical trials. Each contribution includes a discussion about the future of the field and highlights areas of potential growth and their relevance to routine clinical practice over the next decade. The succinctly written chapters will be easily accessible to both neurologists and trainees who have no expertise in the area. Many of the chapters are co-written by a clinician and a basic scientist, and each has been subject to peer review — both by experts in the field and a “jobbing” general neurologist. This has ensured that the contributions reflect contemporary scientific thinking which is presented in a way that is easy to digest. The book includes generous use of diagrams to help explain difficult concepts, a glossary explaining the terminology, and provides information on links to web-based resources for further information."

Contents:

1. Neurogenetics-single gene disorders. Genetic linkage analysis. Linkage disequilibrium and association. Mutational spectrum. Molecular genetic tools. Molecular genetic testing. Animal models. Web-based information for genetic diagnosis and testing.Outlook. Acknowledgements. References

2. Neurogenetics II: complex disorders. Guiding principles. Applications to clinical neurology. Tauopathies. New technologies. Conclusions. Appendix A. Human genetic variation. Appendix B. Genetic linkage and association analyses. References

3. Functional genomics and proteomics: application in neurosciences. Functional genomics. RNA preparation. Differential display. SAGE. Microarrays. Real time Q-PCR. Proteomics. Two dimensional gel electrophoresis. ICAT-isotope coded affinity tags. Protein microarrays. Mass spectrometry. SELDI. Future prospects. Acknowledgements. References

4. Mitochondria. Historical introduction. What are mitochondria and what do they do? The genetic basis of mitochondrial biogenesis. Mitochondrial disease: genotype and phenotype. Mitochondrial genetic factors. Confirming suspected mitochondrial disease. Managing mitochondrial disease- the future. Animal models. Conclusion. Acknowledgements. References

5. Nanotechnology for neuronal ion channels. Channels-essential for neuronal excitability. History of the voltage clamp technique. Application to clinical neurology. Principles behind the techniques. Potential application of the technologies in the future. Conclusions. Acknowledgements. Appendix 1. Glossary of terms. Appendix 2. Associated websites of interest. References

6. Molecular and cellular pathways of neurodegeneration in motor neurone disease. What do we know about the causes of motor neurone degeneration? Genetics of ALS/MND. Oxidative stress. Excitotoxicity. Mitochondrial dysfunction. Cytoskeletal elements and axonal transport. Protein aggregation. Inflammatory cascades and the role of non-neuronal cells. Apoptosis. Cell specific features of motor neurones which may predispose to neurodegeneration. Conclusions. Acknowledgements. References

7. Neurodegenerative disorders: Parkinson's disease and Huntington's disease. Parkinson's disease. Huntington's disease. Conclusions. References

8. Molecular pathogenesis of neuroinflammation. A brief history of immune privilege. Experimental autoimmune encephalomyelitis-an animal model to study interactions of the immune system with the CNS. How modern techniques contributed to our understanding of neuroinflammation in EAE and multiple sclerosis. Microdissection and molecular analyses of single cells involved in the disease process. Novel techniques and their contribution to clinical neurology-a future perspective. Conclusion. Acknowledgements. References

9. Neurovirology. Introduction. Specific techniques and their applications. Acknowledgements. References

10. Molecular neurology of prion disease. Introduction to prions and historical perspective. Molecular biology of prions. Application to clinical neurology. References

11. Monitoring and interpretation of intracranial pressure. Methods of measurement. Typical events and trends in ICP monitoring. Waveform analysis of ICP. Pressure-volume compensatory reserve. Cerebrovascular pressure reactivity. Other methods of ICP analysis. Practical use of the ICP derived parameters: "optimal CPP" and multiple trend analysis. Association with outcome following severe head injury. ICP in hydrocephalus and benign intracranial hypertension. Attempts to measure ICP and CPP non-invasively. Is ICP monitoring useful. Acknowledgements. References

12. Cerebral perfusion and stroke. Cerebrovascular anatomy. Methods for measurement of cerebral blood flow. Regulation of the normal cerebral circulation. Cerebral circulation responses to focal ischaemia. The ischaemic penumbra. Mechanisms of infarction in penumbral tissue. Summary. References

13. A review of structural magnetic resonance neuroimaging. Definition(s) of structural MRI. Applications of structural MRI. The next ten years. Conclusion. Acknowledgements. References

14. Applications of positron emission tomography (PET) in neurology. Principles of PET. Application of PET to clinical neurology. Potential future applications. References

15. Functional magnetic resonance imaging. Principles of functional MRI. Clinical applications of fMRI. fMRI as a marker of pathological state. Linking fMRI to other MRI techniques for characterising pathology and other directions for the future. Acknowledgements. References

16. How to spot bias and other potential problems in randomised controlled trials. Bias. Precision. Analysis and inferences. The future. Conclusions. Acknowledgements. References.

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references and index.

ISBN:

9786611347543

9781281347541

128134754X

9781860948961

1860948960

OCLC:

879025572