The digital patient : advancing healthcare, research, and education / edited by C. Donald Combs, John A. Sokolowski, Catherine M. Banks ; cover image courtesy of Hector M. Garcia.

Format:

Book

Contributor:

Combs, C. Donald, editor.

Sokolowski, John A., 1953- editor.

Banks, Catherine M., 1960- editor.

Garcia, Hector M., cover designer.

Series:

Wiley Series in Modeling and Simulation

Language:

English

Subjects (All):

Simulated patients.

Precision medicine.

Physical Description:

1 online resource (396 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, New Jersey : Wiley, 2016.

Language Note:

English

Summary:

"Medical modeling and simulation technology is interdisciplinary and combines life and physical sciences, engineering, and medical expertise, and since it is being executed at various levels for various purposes at research and development institutions throughout the world, there exists the foremost challenge of conjoining these independent, yet complementary efforts to exploit their full potential. This is especially true with regard to the virtual human wherein there is the necessity to assimilate both the developed and developing components of the human physiome and diseaseome to advance patient care, medical practice, research and development, and education and training. This book advances personalized patient care using the virtual human and its ability to represent the human physiome (how the body functions) and diseaseome (disruptions to the body's functions). In order to achieve a holistic analysis of the body, this book provides an integrated, interoperable, i.e., complex and dynamic, examination of human biology with physiological and behavioral components of the overall patient experience. The future of healthcare is proving to be an overwhelming challenge globally, and changing practice to provide holistic, personalized care in an expanding (longer-lived and growing population) and demanding (multiple pathologies and needs per individual patient) environment requires optimizing research, technology, and training. Clinicians must exploit new generation capabilities in diagnostic and therapeutic patient care for the burden of patient needs to be met. Medical technology is very near to providing safe and effective personalized patient care through the use of virtual human technology, and via simulation, clinicians receive a virtual patient in real-time and conclude a more timely and precise treatment action. With contributions from international experts, the book presents the state-of-the-art in the development of the virtual human physiome in three areas: anatomical; physiological; and behavioral. This is followed by a discussion of current applications in: practice-personalized care; research; and education. With this two-fold research agenda aimed at assimilating the various resources needed to complete the virtual human, the book extends the integrated, interoperable capabilities to further research and development, augment education and training, and advance patient care"--Provided by publisher.

Contents:

Intro

TITLE PAGE

TABLE OF CONTENTS

LIST OF CONTRIBUTORS

PREFACE

EDITORS' NOTE

PART 1: THE VISION: THE DIGITAL PATIENT-IMPROVING RESEARCH, DEVELOPMENT, EDUCATION, AND HEALTHCARE PRACTICE

1 THE DIGITAL PATIENT

HEALTH, THE GOAL

PERSONALIZED MEDICINE

THE BEST OUTCOMES

THE EMERGENCE OF THE DIGITAL PATIENT

THE HUMAN PHYSIOME

ENABLING THE DIGITAL PATIENT

P4 MEDICINE

CONCLUSION

REFERENCES

2 REFLECTING ON DISCIPULUS AND REMAINING CHALLENGES

INTRODUCTION

A BRIEF CONTEXTUAL BACKGROUND AND A CALL FOR INTEGRATION: PERSONALIZED MEDICINE IS HOLISTIC

THE MANY VERSIONS OF THE DIGITAL PATIENT: ON THE ROAD TO MEDICAL AVATARS

DISCIPULUS: THE DIGITAL PATIENT TECHNOLOGICAL CHALLENGES AND MAIN CONCLUSIONS

THE REMAINING CHALLENGES AND BIG DATA

3 ADVANCING THE DIGITAL PATIENT

THE DIGITAL PATIENT: ITS EARLY START

ENGAGING THE DIGITAL PATIENT

4 THE SIGNIFICANCE OF MODELING AND VISUALIZATION

MODELING A COMPLEX SYSTEM: HUMAN PHYSIOLOGY

MEDICAL MODELING, SIMULATION, AND VISUALIZATION

MODES AND TYPES OF VISUALIZATION

VISUALIZATION FOR PATIENT-SPECIFIC USEFULNESS

PART 2: STATE OF THE ART: SYSTEMS BIOLOGY, THE PHYSIOME, AND PERSONALIZED HEALTH

5 THE VISIBLE HUMAN: A GRAPHICAL INTERFACE FOR HOLISTIC MODELING AND SIMULATION

EDUCATION

MODELING

VIRTUAL REALITY TRAINERS AND SIMULATORS

6 THE QUANTIFIABLE SELF: PETABYTE BY PETABYTE

SMARR'S QUANTIFIED SELF

EXTENDING SMARR'S RESEARCH

THE QUANTIFIED SELF-VISION, SIMPLIFIED

CRITICISM

7 SYSTEMS BIOLOGY AND HEALTH SYSTEMS COMPLEXITY: IMPLICATIONS FOR THE DIGITAL PATIENT

SYSTEMS BIOLOGY.

THE INSTITUTE FOR SYSTEMS BIOLOGY

THE COMPLEXITY INSTITUTE

THE POTENTIAL OF SYSTEMS BIOLOGY

8 PERSONALIZED COMPUTATIONAL MODELING FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS

BASICS OF CARDIAC ELECTROPHYSIOLOGY

CARDIAC MODELING ADVANCEMENTS

REGULATION OF INTRACELLULAR CALCIUM

FROM CELLS TO CABLES TO SHEETS TO TISSUE TO THE HEART

WHERE CAN WE GO FROM HERE? WHAT IS THE CARDIAC MODEL IN THE DIGITAL PATIENT?

9 THE PHYSIOME PROJECT, openEHR ARCHETYPES, AND THE DIGITAL PATIENT

MULTISCALE PHYSIOLOGICAL PROCESSES

PHYSIOME PROJECT STANDARDS, REPOSITORIES, AND TOOLS

ARCHETYPE SPECIALIZATION

ARCHETYPE DEFINITION LANGUAGE

LINKING ARCHETYPES TO EXTERNAL KNOWLEDGE SOURCES (TERMINOLOGY AND BIOMEDICAL ONTOLOGIES)

ARCHETYPE ANNOTATIONS

OpenEHR MODEL REPOSITORY AND GOVERNANCE

FAST HEALTHCARE INTEROPERABILITY RESOURCES

A DISEASE SCENARIO

SUMMARY AND CONCLUSIONS

10 PHYSICS-BASED MODELING FOR THE PHYSIOME

MODELING SCHEMES

FUTURE CHALLENGES

ACKNOWLEDGMENTS

11 MODELING AND UNDERSTANDING THE HUMAN BODY WITH SwarmScript

RELATED WORK

MULTIAGENT ORGANIZATION

DESIGNING INTERACTIVE AGENTS

SPEAKING SwarmScript

ANSWERING DEMAND: THE DESIGN OF SwarmScript

GRAPH-BASED RULE REPRESENTATION

THE SOURCE-ACTION-TARGET

SwarmScript INTO3D

A SwarmScript DIALOGUE

DISCUSSION

SUMMARY

12 USING AVATARS AND AGENTS TO PROMOTE REAL-WORLD HEALTH BEHAVIOR CHANGES

AVATARS AND AGENTS

USING AGENTS AND AVATARS TO PROMOTE HEALTH BEHAVIOR CHANGES

References

13 VIRTUAL REALITY AND EATING, DIABETES, AND OBESITY

VIRTUAL REALITY

References.

14 IMMERSIVE VIRTUAL REALITY TO MODEL PHYSICAL: SOCIAL INTERACTION AND SELF-REPRESENTATION

THEORY FOR IMMERSIVE VIRTUAL LEARNING SPACES

PART 3: CHALLENGES: ASSIMILATING THE COMPREHENSIVE DIGITAL PATIENT

15 A ROADMAP FOR BUILDING A DIGITAL PATIENT SYSTEM

APPROACH

BUILDING THE DIGITAL PATIENT THROUGH INTEROPERABILITY

ACKNOWLEDGMENT

16 MULTIDISCIPLINARY, INTERDISCIPLINARY, AND TRANSDISCIPLINARY RESEARCH: CONTEXTUALIZATION AND RELIABILITY OF THE COMPOSITE

INTERDISCIPLINARITY AND INTERDISCIPLINARY RESEARCH

BASE OBJECT MODELS TO SUPPORT TRANSDISCIPLINARITY AND COMPOSABILITY

OPEN CHALLENGES ON RELIABILITY

SUMMARY AND CONCLUSION

17 BAYES NET MODELING: THE MEANS TO CRAFT THE DIGITAL PATIENT

OTHER INTERESTING APPLICATIONS

PART 4: POTENTIAL IMPACT: ENGAGING THE DIGITAL PATIENT

18 VIRTUAL REALITY STANDARDIZED PATIENTS FOR CLINICAL TRAINING

THE RATIONALE FOR VIRTUAL STANDARDIZED PATIENTS

CONVERSATIONAL VIRTUAL HUMAN AGENTS

USC EFFORTS TO CREATE VIRTUAL STANDARDIZED PATIENTS

19 THE DIGITAL PATIENT: CHANGING THE PARADIGM OF HEALTHCARE AND IMPACTING MEDICAL RESEARCH AND EDUCATION

OVERVIEW DIGITAL MEDICINE PROJECTS

PERSONALIZED PATIENT CARE CLINICAL USE

RECOMMENDED EDUCATION AND TRAINING FOR VPH PROJECT PARTICIPATION

FROM FLEXNER TO THE 2010 CARNEGIE REPORT

SUMMARY STATEMENTS

20 THE DIGITAL PATIENT: A VISION FOR REVOLUTIONIZING THE ELECTRONIC MEDICAL RECORD AND FUTURE HEALTHCARE

APPLICATIONS OF THE DIGITAL PATIENT AS THE EMR

21 REALIZING THE DIGITAL PATIENT

INDEX

MODELING AND SIMULATION.

END USER LICENSE AGREEMENT.

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters and index.

Description based on print version record.

ISBN:

9781118952771

1118952774

9781118952788

1118952782

9781118952764

1118952766

OCLC:

933596664