Stem cells and regenerative medicine Volume VII, Diseases and therapy / Philippe Taupin.

Format:

Book

Author/Creator:

Taupin, Philippe.

Series:

Stem Cells and Regenerative Medicine

Stem cells and regenerative medicine, 2159-8754 ; v. 7

Language:

English

Subjects (All):

Stem cells.

Regenerative medicine.

Physical Description:

1 online resource (238 p.)

Edition:

1st ed.

Place of Publication:

New York : Nova Science Publishers, Inc., 2012.

Language Note:

English

Summary:

Stem cells are the building blocks of the body and can develop into any of the cells that make up our bodies. Stem cells carry a lot of hope for the treatment of a broad range of diseases and injuries, spanning from cancers, diabetes, genetic diseases, graft-versus-host disease, eye, heart and liver diseases, inflammatory and autoimmune disorders, to neurological diseases and injuries, particularly neurodegenerative diseases, like Alzheimer's and Parkinson's disease and many others. This book provides an overview and in-depth analysis of recent developments in stem cell research and therapy. It is composed of recently published review articles that went through a peer-review process.

Contents:

Intro

STEM CELLS AND REGENERATIVE MEDICINE VOLUME VII DISEASES AND THERAPY

Contents

Introduction Adult Neurogenesis and Neural Stem Cells: Developmental and Therapeutic Potential

Acknowledgments

Chapter I Enhanced Neurogenesis following Neurological Disease

Abstract

Adult Neurogenesis in Alzheimer's Disease and in Neurodegenerative Diseases of the Brain

Huntington's Disease

Parkinson's Disease

Adult Neurogenesis in Epilepsy

Function of the Newly Generated Neuronal Cells in Neurological Diseases

Therapy

Stimulation of Endogenous Neural Progenitor Cells

Transplantation

Conclusions

References

Chapter II Alzheimer's Disease: Increased Neurogenesis and Possible Disease Mechanisms Related to Neurogenesis

Etiology and Pathology of Alzheimer' s Disease

Amyloid Plaques and Neurofibrillary Tangles

Genetic Factors and Mutations

Aneuploidy

Enhanced Neurogenesis

Possible Mechanisms Related to Adult Neurogenesis

Aneuploidy in AD Patients

Aneuploidy for Chromosome 21 and Amyloid Deposits

Aneuploidy for Chromosome 17 and Neurofibrillary Tangles Formation

Aneuploidy for Chromosomes 1, 14 and 19 and Pathogenesis of AD

Aneuploidy and Adult Neurogenesis

Factors Promoting Aneuploidy in Alzheimer's Disease

Hyperphosphorylation of Tau Protein

Mutation in PSEN1

Modulation of Adult Neurogenesis

Oxidative Stress

Conclusion and Perspectives

Chapter III Neurogenesis, NSCs, Pathogenesis and Therapies for Alzheimer's Disease

Abbreviations

Introduction

Adult Neurogenesis and Neural Stem Cells

Neurogenesis in the Adult Brain of Mammals

Neural Progenitor and Stem Cells In Vitro.

Modulation of Adult Neurogenesis In Vivo

Cellular Therapy

Alzheimer's Disease

A Senile Dementia and Neurodegenerative Disease

Genetic Mutations and Risks Factors in Alzheimer's Disease

Aneuploidy in Region of Neurodegeneration

Adult Neurogenesis and the Pathogenesis of Alzheimer's Disease

Neurogenesis in Alzheimer's Disease

Aneuploid Newly Generated Neuronal Cells in the Adult Brain with Alzheimer's Disease

Novel Drug Targets for Alzheimer's Disease

Newly Generated Neuronal Cells of the Adult Brain

Aneuploid Newly Generated Neuronal Cells of the Adult Brain

Summary and Perspectives

Chapter IV Adult Neurogenesis and Drug Therapy*

Neurogenesis in the Adult Mammalian Brain

Neurogenesis and Neurological Diseases, Disorders and Injuries

Neurogenesis in Neurodegenerative Diseases and Disorders

Neurogenesis and Injuries

Discussion

Stimulation of Neurogenesis

Drug Therapy

Conclusion

Chapter V Neurogenic Factors Are Targets in Depression

Adult Neurogenesis and Depression

Adult Neurogenesis and the Pharmacology of Depression

The Hippocampus and Depression

Limitations of Paradigms and Models to Study Adult Neurogenesis and Depression

Chapter VI Pharmacology of Adult Neurogenesis: Compensatory and Regenerative Processes

Pharmacology of Adult Neurogenesis in Alzheimer's Disease

Alzheimer's Disease and Drug Therapy

Adult Neurogenesis and Alzheimer's Disease Drugs

Pharmacology of Adult Neurogenesis in Depression

Depression and Antidepressants

Adult Neurogenesis and Antidepressants

Discussion.

Drug Therapy: Compensatory Processes

Adult Neurogenesis in Neurological Diseases and Disorders: Regenerative Processes

Adult Neural Stem Cells and Regenerative Medicine

Chapter VII Adult Neurogenesis, Neuroinflammation, and Therapeutic Potential of Adult Neural Stem Cells

Neurogenesis and Neural Stem Cells in the Adult CNS

Adult Neurogenesis in Neurological Diseases and Disorders

Depression

Epilepsy

Therapeutic Potential of Adult Neural Stem Cells

Stimulation of Neural Progenitor or Stem Cells of the Adult CNS

Transplantation of Neural Progenitor and Stem Cells of the Adult CNS

Neuroinflammation and the Therapeutic Potential of Adult NSCs

Neuroin ammation in Neurological Diseases and Injuries

Neuroin ammation in Adult Neurogenesis

Neuroin ammation and Neural Progenitor and Stem Cell Transplantation

Limitations and Pitfalls of BrdU Labelling for Studying Neurogenesis

Conclusions and Perspectives

Chapter VIII A Dual Activity of ROS and Oxidative Stress on Adult Neurogenesis and Alzheimer's Disease*

Alzheimer's Disease Is Caused by Excessive Rate of Genome Damage

Enhanced Neurogenesis in Alzheimer's Disease

Oxidative Stress Contributes to the Pathogenesis of Alzheimer's Disease

A Dual Activity of ROS and Oxidative Stress on Adult Neurogenesis and on the Pathogenesis of Alzheimer's Disease

ROS and Oxidative Stress Control the Cell Cycle and Genomic Stability

Concluding Remarks

Chapter IX Adult Neurogenesis and Neural Stem Cells as a Model for the Discovery and Development of Novel Drugs

Introduction.

Adult Neurogenesis and Drugs to Treat Neurological Diseases and Disorders

Adult Neurogenesis and NSCs Are Targets of Drugs Used for Treating Neurological Diseases and Disorders

Neurogenic Drugs to Reverse or Compensate Deficits and Impairments Associated with the Hippocampus

Expert Opinion

Adult NSCs: A Promising Model to Discover and Develop Neurogenic Drugs

Limitations and Pitfalls of Adult NSCs for Discovering and Developing Neurogenic Drugs

Declaration of Interest

Bibliography

Chapter X Neurogenic Drugs and Compounds*

Recent patents on Compounds and Drugs Modulating Neurogenesis in the Adult Brain Nootropic Agents

The Activity of 15 Compounds and their Derivatives

Apigenin and Related Compounds

Current and Future Developments

Conflict of Interest

Chapter XI Very Small Embryonic-like Stem Cells for Regenerative Medicine*

Background

Methods

Results

Chemistry

Biology and Action

Chapter XII Transplantation of Cord Blood Stem Cells for Treating Hematologic Diseases and Strategies to Improve Engraftment

Executive Summary

HSCs and Cord Blood Stem Cells

Selectins and the Homing of HSCs

P- and E-selectins and Selectin Glycoprotein Ligands

Homing of Hematopoietic Progenitor and Stem Cells of the BM and CB

Transplantation of Cord Blood Stem Cells for the Treatment of Hematologic Diseases

Total Nucleated Cell Count and Age of Patients

Early Infections and Delayed Engraftment

Graft-versus-Host Disease

Strategies to Improve the Outcome of CB Transplantation for the Treatment of Hematologic Diseases.

Direct Delivery of Cord Blood Stem Cells to the Bone Marrow

Transplantation of Double Cord Blood Units

Fucosylation of Selectin Glycoprotein Ligands Ex Vivo

Expansion and Propagation of Cord Blood Stem Cells In Vitro

Future Perspectives

Financial and Competing Interests Disclosure

Chapter XIII Transplantation of Two Populations of Stem Cells to Improve Engraftment*

Transplant

Chapter XIV Ex Vivo Fucosylation of Stem Cells to Improve Engraftment*

Objective

In Vivo and In Vitro Studies

Fucosyltransferases

Chapter XV Thirteen Compounds Promoting Oligodendrocyte Progenitor Cell Differentiation and Remyelination for Treating Multiple Sclerosis

Chemistry and Synthesis

Culture of Oligodendrocyte Progenitor Cells

Cerebellar Organotypic Cultures and Lysolecithin Demyelination

Zebrafish Model

Cuprizone-mediated Demyelination Mouse Model

Other Assays

Drug Screenings

Primary Screening

Secondary Screening

Chapter XVI Antibodies against CD20 (Rituximab) for Treating Multiple Sclerosis

Acknowledgments.

Bibliography.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-62081-121-9

OCLC:

923665378