Wintrobe's clinical hematology / editors, John P. Greer, MD, Professor, Departments of Medicine and Pediatrics, Divisions of Hermatology/Oncology, Vanderbilt University Medical Center, Nashville, Tennessee ; Daniel A. Arber, MD, Professor and Vice Chair, Department of Pathology, Stanford University, Director of Anatomic and Clinical Pathology Services, Stanford University Medical Center, Stanford, California ; Bertil Glader, MD, Professor, Departments of Pediatrics and Pathology, Stanford University Medical Center, Stanford, California, Lucile Packard Children's Hospital, Palo Alto, California ; Alan F. List, MD, Senior Member, Department of Malignant Hematology, President and CEO, Moffit Cancer Center, Tampa Florida ; Robert T. Means Jr., MD, PhD, Professor of Internal Medicine, Executive Dean, University of Kentucky College of Medicine, Lexington, Kentucky ; Frixos Paraskevas, MD, Professor of Internal Medicine and Immunology (Retired), University of Mantioba Medical School, Associate Member, Institute of Cell Biology-Cancer Care, Mantioba, Winnipeg, Mantioba, Canada ; George M. Rodgers, MD, Professor of Medicine and Pathology, University of Utah School of Medicine, Health Sciences Center, Medical Director, Coagulation Laboratory, ARUB Laboratories, Salt Lake City, Utah ; Editor Emeritus, John Foerster, MD, FRCPC, Professor and Physician Emertius, Winnipeg, Canada.

Format:

Book

Contributor:

Greer, John P., editor.

Language:

English

Subjects (All):

Blood.

Hematologic Diseases.

Hematology--methods.

Hematology.

Blood--Diseases.

Medical Subjects:

Blood.

Hematologic Diseases.

Hematology--methods.

Physical Description:

1 online resource (xxvii, 2,278 pages) : illustrations (some color)

Edition:

Thirteenth edition.

Other Title:

Clinical hematology

Place of Publication:

Philadelphia : Wolters Kluwer, Lippincott Williams & Wilkins Health, [2014]

Language Note:

English

Summary:

"With the 13th edition of "Wintrobe's Clinical Hematology", Dr. Greer brings forth another text that bridges the gap between the clinical practice of hematology and the basic foundations of science. Revised to include a greater emphasis placed on biology and pathophysiology, this book offers the reader a clear understanding of the relationship between basic molecular biology and every aspect of the clinical practice of hematology. Coupled with this comprehensive overview, Dr. Greer presents a clear focus on clinical diagnosis and treatment of disease. Dr. Greer has added 7 entirely new chapters that are concisely reduced and dived in order to present more focused material. Additionally, the text provides a special section dedicated to transplantation, international editors, and over 1,400 full-color illustrations. This latest edition is an excellent resource for anyone studying Hemotology, Oncology, Internal Medicine, or Pathology. Features: 30% of the chapters have additional or new contributors, greater emphasis on molecular genetics and pathophysiology, increased number of hematopathology illustrations, diagrams, figures, standard and electron micrographs, algorithms, schemas, and protocols--all in color, 4-color halftones and 2-color computer generated illustrations spread throughout the book to reinforce understanding and application of method. The last three new chapters are entirely dedicated to Transplantation"--Provided by publisher.

Contents:

Wintrobe's Clinical Hematology, Thirteenth Edition

Half Title Page

Title Page

Copyright

Dedication

CONTRIBUTORS

PREFACE

ACKNOWLEDGMENTS

CONTENTS

INTRODUCTION: THE DIAGNOSTIC AND THERAPEUTIC APPROACH TO HEMATOLOGIC PROBLEMS

PART 1: Laboratory Hematology

CHAPTER 1: EXAMINATION OF THE BLOOD AND BONE MARROW

CHAPTER 2: CLINICAL FLOW CYTOMETRY

CHAPTER 3: CYTOGENETICS

CHAPTER 4: MOLECULAR DIAGNOSIS IN HEMATOLOGY

PART II: The Normal Hematologic System

CHAPTER 5: ORIGIN AND DEVELOPMENT OF BLOOD CELLS

CHAPTER 6: THE BIRTH, LIFE, AND DEATH OF RED BLOOD CELLS: ERYTHROPOIESIS, THE MATURE RED BLOOD CELL, AND CELL DESTRUCTION

CHAPTER 7: NEUTROPHILIC LEUKOCYTES

CHAPTER 8: THE HUMAN EOSINOPHIL

CHAPTER 9: MAST CELLS AND BASOPHILS: ONTOGENY, CHARACTERISTICS, AND FUNCTIONAL DIVERSITY

CHAPTER 10: MONOCYTES, MACROPHAGES, AND DENDRITIC CELLS

CHAPTER 11: LYMPHOCYTES AND LYMPHATIC ORGANS

CHAPTER 12: B LYMPHOCYTES

CHAPTER 13: T LYMPHOCYTES AND NATURAL KILLER CELLS

CHAPTER 14: EFFECTOR MECHANISMS IN IMMUNITY

CHAPTER 15: MEGAKARYOCYTES

CHAPTER 16: PLATELET STRUCTURE AND FUNCTION IN HEMOSTASIS AND THROMBOSIS

CHAPTER 17: PLATELET FUNCTION IN HEMOSTASIS AND THROMBOSIS

CHAPTER 18: BLOOD COAGULATION AND FIBRINOLYSIS

CHAPTER 19: ENDOTHELIUM: ANGIOGENESIS AND THE REGULATION OF HEMOSTASIS

PART III: Transfusion Medicine

CHAPTER 20: RED CELL, PLATELET, AND WHITE CELL ANTIGENS

CHAPTER 21: TRANSFUSION MEDICINE

PART IV: Disorders of Red Cells

CHAPTER 22: ANEMIA: GENERAL CONSIDERATIONS

CHAPTER 23: IRON DEFICIENCY AND RELATED DISORDERS

CHAPTER 24: SIDEROBLASTIC ANEMIAS

CHAPTER 25: HEMOCHROMATOSIS

CHAPTER 26: PORPHYRIAS

CHAPTER 27: HEREDITARY SPHEROCYTOSIS, HEREDITARY ELLIPTOCYTOSIS, AND OTHER DISORDERS ASOCIATED WITH ABNORMALITIES OF THE ERYTHROCYTE MEMBRANE.

CHAPTER 28: HEREDITARY HEMOLYTIC ANEMIAS DUE TO RED BLOOD CELL ENZYME DISORDERS

CHAPTER 29: AUTOIMMUNE HEMOLYTIC ANEMIA

CHAPTER 30: HEMOLYTIC DISEASE OF THE FETUS AND NEWBORN

CHAPTER 31: PAROXYSMAL NOCTURNAL HEMOGLOBINURIA

CHAPTER 32: ACQUIRED NONIMMUNE HEMOLYTIC DISORDERS

CHAPTER 33: SICKLE CELL ANEMIA AND OTHER SICKLING SYNDROMES

CHAPTER 34: THALASSEMIAS AND RELATED DISORDERS: QUANTITATIVE DISORDERS OF HEMOGLOBIN SYNTHESIS

CHAPTER 35: HEMOGLOBINS WITH ALTERED OXYGEN AFFINITY, UNSTABLE HEMOGLOBINS, M-HEMOGLOBINS, AND DYSHEMOGLOBINEMIAS

CHAPTER 36: MEGALOBLASTIC ANEMIAS: DISORDERS OF IMPAIRED DNA SYNTHESIS

CHAPTER 37: INHERITED APLASTIC ANEMIA SYNDROMES

CHAPTER 38: ACQUIRED APLASTIC ANEMIA

CHAPTER 39: RED CELL APLASIA: ACQUIRED AND CONGENITAL DISORDERS

CHAPTER 40: CONGENITAL DYSERYTHROPOIETIC ANEMIAS

CHAPTER 41: ANEMIAS SECONDARY TO CHRONIC DISEASE AND SYSTEMIC DISORDERS

CHAPTER 42: ANEMIAS DURING PREGNANCY AND THE POSTPARTUM PERIOD

CHAPTER 43: ANEMIAS UNIQUE TO THE FETUS AND NEONATE

CHAPTER 44: ERYTHROCYTOSIS

PART V: Disorders of Hemostasis and Coagulation

CHAPTER 45: DIAGNOSTIC APPROACH TO THE BLEEDING DISORDERS

CHAPTER 46: THROMBOCYTOPENIA: PATHOPHYSIOLOGY AND CLASSIFICATION

CHAPTER 47: THROMBOCYTOPENIA CAUSED BY IMMUNOLOGIC PLATELET DESTRUCTION

CHAPTER 48: THROMBOTIC THROMBOCYTOPENIC PURPURA, HEMOLYTIC-UREMIC SYNDROME, AND RELATED DISORDERS

CHAPTER 49: MISCELLANEOUS CAUSES OF THROMBOCYTOPENIA

CHAPTER 50: BLEEDING DISORDERS CAUSED BY VASCULAR ABNORMALITIES

CHAPTER 51: THROMBOCYTOSIS AND ESSENTIAL THROMBOCYTHEMIA

CHAPTER 52: QUALITATIVE DISORDERS OF PLATELET FUNCTION

CHAPTER 53: INHERITED COAGULATION DISORDERS

CHAPTER 54: ACQUIRED COAGULATION DISORDERS

CHAPTER 55: THROMBOSIS AND ANTITHROMBOTIC THERAPY.

PART VI: Benign Disorders of Leukocytes, the Spleen, and/or Immunoglobins

CHAPTER 56: DIAGNOSTIC APPROACH TO MALIGNANT AND NONMALIGNANT DISORDERS OF THE PHAGOCYTIC AND IMMUNE SYSTEMS

CHAPTER 57: NEUTROPENIA

CHAPTER 58: QUALITATIVE DISORDERS OF LEUKOCYTES

CHAPTER 59: LYSOSOMAL ABNORMALITIES OF THE MONOCYTE-MACROPHAGE SYSTEM: GAUCHER AND NIEMANN-PICK DISEASES

CHAPTER 60: LANGERHANS CELL HISTIOCYTOSIS

CHAPTER 61: PATHOLOGY OF LANGERHANS CELL HISTIOCYTOSIS AND OTHER HISTIOCYTIC PROLIFERATIONS

CHAPTER 62: INFECTIOUS MONONUCLEOSIS AND OTHER EPSTEIN-BARR VIRUS-RELATED DISORDERS

CHAPTER 63: PRIMARY IMMUNODEFICIENCY SYNDROMES

CHAPTER 64: ACQUIRED IMMUNODEFICIENCY SYNDROME

CHAPTER 65: DISORDERS OF THE SPLEEN

CHAPTER 66: TUMORS OF THE SPLEEN

PART VII: Hematologic Malignancies

CHAPTER 67: HEMATOPOIETIC NEOPLASMS: PRINCIPLES OF PATHOLOGIC DIAGNOSIS

CHAPTER 68: PRINCIPLES AND PHARMACOLOGY OF CHEMOTHERAPY

CHAPTER 69: SUPPORTIVE CARE IN HEMATOLOGIC MALIGNANCIES

CHAPTER 70: IMMUNOTHERAPY

CHAPTER 71: GENE THERAPY FOR HEMATOLOGIC DISORDERS

CHAPTER 72: MOLECULAR GENETICS OF ACUTE LEUKEMIA

CHAPTER 73: DIAGNOSIS AND CLASSIFICATION OF THE ACUTE LEUKEMIAS AND MYELODYSPLASTIC SYNDROMES

CHAPTER 74: ACUTE LYMPHOBLASTIC LEUKEMIA IN ADULTS

CHAPTER 75: ACUTE MYELOID LEUKEMIA IN ADULTS

CHAPTER 76: ACUTE LYMPHOBLASTIC LEUKEMIA IN CHILDREN

CHAPTER 77: ACUTE MYELOGENOUS LEUKEMIA IN CHILDREN

CHAPTER 78: ACUTE PROMYELOCYTIC LEUKEMIA

CHAPTER 79: THE MYELODYSPLASTIC SYNDROMES

CHAPTER 80: PATHOLOGY OF THE MYELOPROLIFERATIVE NEOPLASMS

CHAPTER 81: CHRONIC MYELOID LEUKEMIA

CHAPTER 82: POLYCYTHEMIA VERA

CHAPTER 83: MYELOFIBROSIS

CHAPTER 84: EOSINOPHILIC NEOPLASMS AND HYPEREOSINOPHILIC SYNDROME

CHAPTER 85: SYSTEMIC MASTOCYTOSIS

CHAPTER 86: DIAGNOSIS AND CLASSIFICATION OF LYMPHOMAS.

CHAPTER 87: MOLECULAR GENETIC ASPECTS OF NON-HODGKIN LYMPHOMAS

CHAPTER 88: NON-HODGKIN LYMPHOMA IN ADULTS

CHAPTER 89: NON-HODGKIN LYMPHOMA IN CHILDREN

CHAPTER 90: CHRONIC LYMPHOCYTIC LEUKEMIA

CHAPTER 91: HAIRY CELL LEUKEMIA

CHAPTER 92: CUTANEOUS T-CELL LYMPHOMA: MYCOSIS FUNGOIDES AND SÉZARY SYNDROME

CHAPTER 93: HODGKIN LYMPHOMA IN ADULTS

CHAPTER 94: HODGKIN LYMPHOMA IN CHILDREN

CHAPTER 95: PRACTICAL APPROACH TO EVALUATION OF MONOCLONAL GAMMOPATHIES

CHAPTER 96: MOLECULAR GENETIC ASPECTS OF PLASMA CELL DISORDERS

CHAPTER 97: MONOCLONAL GAMMOPATHIES OF UNDETERMINED SIGNIFICANCE AND SMOLDERING MULTIPLE MYELOMA

CHAPTER 98: MULTIPLE MYELOMA

CHAPTER 99: IMMUNOGLOBULIN LIGHT-CHAIN AMYLOIDOSIS (PRIMARY AMYLOIDOSIS)

CHAPTER 100: WALDENSTRÖM MACROGLOBULINEMIA

CHAPTER 101: POEMS SYNDROME, CRYOGLOBULINEMIA, AND HEAVY-CHAIN DISEASE

PART VIII: Transplantation

CHAPTER 102: HEMATOPOIETIC CELL TRANSPLANTATION

CHAPTER 103: HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR NONMALIGNANT DISORDERS

CHAPTER 104: ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION (HCT) FOR HEMATOLOGIC MALIGNANCIES

CHAPTER 105: GRAFT-VERSUS-HOST DISEASE AND GRAFT-VERSUS-TUMOR RESPONSE

CHAPTER 106: LATE EFFECTS AFTER TRANSPLANTATION

Appendices

APPENDIX A: CLUSTERS OF DIFFERENTIATION

CELL MEMBRANE PROTEINS

PROTEIN FAMILIES

COMPLEMENT CONTROL PROTEIN DOMAIN

CLUSTERS OF DIFFERENTIATION

CD2 (T-11, LEU-5, SRBC RECEPTOR)

CD3 (T3, LEU-4)

CD4 (T4, LEU-3A, 3B)

CD5 (LEU-1)

CD6

CD7

CD8 (T-8, LEU-2)

CD9

CD10 (COMMON ACUTE LYMPHOCYTIC LEUKEMIA ANTIGEN, NEPRILYSIN).

CD11A (LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1α SUBUNIT)

CD11B (α-M, CR-3, MAC 1)

CD11C (INTEGRIN αX, P150)

CD11D (α-D)

CD13 (MY-7, AMINOPEPTIDASE N)

CD14 (LIPOPOLYSACCHARIDE RECEPTOR)

CD15 (LEWISX, CD15-S, SIALYL-LEWISX).

CD16 (FCGR-III)

CD18 (β-2 INTEGRIN)

CD19 (B4)

CD20 (B1)

CD21 (CR2, EPSTEIN-BARR VIRUS RECEPTOR, C3D RECEPTOR)

CD22 (B-5, LEU-14)

CD23 (LEU-20, BLAST-2, FCεR-II)

CD24

CD25 (TAC ANTIGEN, α-CHAIN OF INTERLEUKIN-2 RECEPTOR)

CD27

CD28

CD29 (β1 INTEGRIN CHAIN, VERY LATE ANTIGEN β-CHAIN, PLATELET GLYCOPROTEIN IIa)

CD30 (KI-1, BERH2 ANTIGEN)

CD31 (PLATELET ENDOTHELIAL CELL ADHESION MOLECULE-1)

CD32 (FCGR2)

CD33 (THE SIALIC ACID-BINDING IMMUNOGLOBULIN SUPERFAMILY LECTIN-3)

CD34 (MY10, SGP90)

CD35 (COMPLEMENT RECEPTOR 1: CR1, C3BR, C4BR)

CD36 (PLATELET GLYCOPROTEIN IV)

CD38 (ADENOSINE DIPHOSPHATE - RIBOSYLCYCLASE, CYCLIC ADENOSINE DIPHOSPHATE, RIBOSE HYDROLASE).

CD39 (ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE-1, APYRASE, ECTOADENOSINE TRIPHOSPHATASE)

CD40

CD41 (INTEGRIN α-IIB SUBUNIT, PLATELET GLYCOPROTEIN IIB OF THE IIB/IIIA COMPLEX)

CD42: CD42A (GPIX)

CD42B (GPIBα)

CD42C (GPIBβ)

CD42D (GPV)

CD43 (LEUKOSIALIN, SIALOPHORIN, WISKOTT-ALDRICH SYNDROME PROTEIN)

CD44 (PHAGOCYTIC GLYCOPROTEIN -1)

CD45 (LEUKOCYTE COMMON ANTIGEN, B220)

CD46 (COMPLEMENT MEMBRANE COFACTOR PROTEIN)

CD47 (INTEGRIN-ASSOCIATED PROTEIN, RH-ASSOCIATED PROTEIN, NEUROPHILIN)

CD48 (BLAST)

CD49: CD49A (VLA-1) TO CD49F (VLA-6)

CD50 (ICAM3

ICAM RECEPTOR)

CD51 (α-SUBUNIT OF VITRONECTIN RECEPTOR, INTEGRIN αV-SUBUNIT)

CD52 (CAMPATH-1)

CD54 (INTERCELLULAR ADHESION MOLECULE 1)

CD55 (COMPLEMENT DECAY-ACCELERATING FACTOR)

CD56 (NEURAL CELL ADHESION MOLECULE)

CD57 (HUMAN NATURAL KILLER CELL-1 ANTIGEN, LEU7 ANTIGEN)

CD58 (LEUKOCYTE FUNCTION ANTIGEN-3)

CD59 (COMPLEMENT PROTECTIN

MEMBRANE INHIBITOR REACTIVE LYSIS

HOMOLOGOUS RESTRICTION FACTOR 20)

CD61 (INTEGRIN β3 SUBUNIT)

CD62 (SELECTINS)

CD63 (GRANULOPHYSIN)

CD64 (FCGR1).

CD66 (CARCINOEMBRYONIC ANTIGEN FAMILY).

Notes:

"Includes fulltext online with regular content updates."

Includes bibliographical references and index.

ISBN:

9781469838205

1469838206

9781469846231

1469846233

9781469846224

1469846225

OCLC:

908512902