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Gynaecological oncology for the MRCOG and beyond / edited by Nigel Acheson and David Luesley.

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Ebook Central College Complete Available online

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Format:
Book
Contributor:
Acheson, Nigel, editor.
Luesley, David, editor.
Royal College of Obstetricians and Gynaecologists (Great Britain), issuing body.
Series:
MRCOG and beyond series.
MRCOG and beyond series
Language:
English
Subjects (All):
Generative organs, Female--Cancer.
Generative organs, Female.
Generative organs, Female--Diseases--Diagnosis.
Generative organs, Female--Surgery--Complications.
Gynecology--Great Britain--Examinations--Study guides.
Gynecology.
Physical Description:
1 online resource (ix, 261 pages) : digital, PDF file(s).
Edition:
2nd ed.
Other Title:
Gynaecological Oncology for the MRCOG & Beyond
Place of Publication:
London : RCOG Press, 2010.
Summary:
A multidisciplinary approach to the care of women with gynaecological cancer - with treatment delivered in linked local or specialist centres - has been established in the UK. The second edition of this book therefore includes chapters which focus on the multidisciplinary approach. Chapters on pathology, radiology, chemotherapy and radiotherapy will increase understanding of these disciplines that are central to the care of women with gynaecological cancers. Chapters on laparoscopic surgery, basic surgical principles, palliative care, emergencies and treatment-related complications provide additional information. All content has been updated to reflect current practice and present the latest evidence on investigation, staging and management. The book is primarily designed to provide a comprehensive summary for candidates preparing for the Part 2 MRCOG examination, and as such covers the RCOG curriculum for gynaecological oncology. It is also a valuable guide for all healthcare professionals working in the field, including trainees, consultants and midwives.
Contents:
Intro
Title page
Contents
About the authors
Preface
Introduction to the second edition
Abbreviations
1 Basic epidemiology
Introduction
Cervical cancer
CERVICAL CANCER AND HUMAN PAPILLOMAVIRUS
RISK FACTORS
Oncogenes
Genotype
Smoking
Hormonal contraception
Dietary factors
Endometrial cancer
Obesity
Polycystic ovary syndrome
Parity
Oral contraceptive pill
Unopposed estrogen hormone replacement therapy
Anti-estrogens
Feminising ovarian tumours
Diabetes and hypertension
Endometrial hyperplasia
Ovarian cancer
Genetic predisposition
Oral contraceptive use
Infertility
Hormone replacement therapy
Ovarian irritation
Ovarian/peritoneal disease
Squamous vulval cancer
Squamous vulval intraepithelial neoplasia
Lichen sclerosus
KEY POINTS
References
2 Basic pathology of gynaecological cancer
Sending specimens to the laboratory
FIXATION
THE REQUEST FORM
FROZEN SECTIONS
Pathology of neoplasia and pre-neoplasia of the female genital tract
CERVIX
Cervical intraepithelial neoplasia
Cervical glandular intraepithelial neoplasia
Stratified mucinous intraepithelial lesion
Invasive squamous carcinoma
Invasive adenocarcinoma
Adenosquamous carcinoma
ENDOMETRIUM
Endometrial carcinoma
Uterus
MIXED TUMOURS OF THE UTERUS
TUMOURS OF THE UTERINE WALL
Endometrial stromal tumours
Smooth muscle tumours of the uterus
Ovary
OVARIAN TUMOURS
Borderline serous tumours
Micropapillary serous carcinoma
OVARIAN CARCINOMA
Vulva
VULVAL INTRAEPITHELIAL NEOPLASIA
SQUAMOUS-CELL CARCINOMA
VERRUCOUS CARCINOMA
EXTRAMAMMARY PAGET'S DISEASE
MELANOMA
PERITONEAL PATHOLOGY.
Special studies in pathology
HISTOCHEMISTRY
IMMUNOHISTOCHEMISTRY AS A DIAGNOSTIC TOOL
Extramammary Paget's disease
Evaluating spindle tumours of the myometrium
Glandular lesions of the cervix
Peritoneal mesothelioma and serous carcinoma in the peritoneum
PROGNOSTIC VALUE OF IMMUNOHISTOCHEMICAL MARKERS
Tumour microstaging
Markers to predict response to therapy
Molecular pathology
3 Preinvasive disease of the lower genital tract
Preinvasive disease and terminology
Human papillomaviruses
DISEASE PREVENTION
IMMORTALISATION AND TRANSFORMATION
The NHS cervical screening programme
RATES OF ABNORMALITY
FURTHER INVESTIGATIONS
THE COLPOSCOPIC EXAMINATION
Glandular premalignancy of the cervix: adenocarcinoma in situ
Vulval intraepithelial neoplasia
Vaginal intraepithelial neoplasia
4 Radiological assessment
DIFFERENTIATING BENIGN FROM MALIGNANT OVARIAN MASSES
PATIENTS WITH FEATURES IN KEEPING WITH MALIGNANCY AT ULTRASOUND
MONITORING THERAPY AND RECURRENT DISEASE
COMPLICATIONS
WHO SHOULD HAVE IMAGING?
TUMOUR VOLUME
Tumour confined to the cervix
Parametrial extension
CONFIRMING THAT THE TUMOUR IS CONFINED TO THECERVIX
NODAL STATUS
RADIOTHERAPY
RECURRENT DISEASE AND COMPLICATIONS
Rarer gynaecological tumours
SARCOMAS
GESTATIONAL TROPHOBLASTIC TUMOUR
VAGINAL CANCER
VULVAL CANCER
5 Surgical principles
Diagnosis
Staging
Treatment
Reconstruction
Palliation
Complications of laparotomy
Ovarian carcinoma
PRIMARY SURGERY
INTERVAL SURGERY
SECOND-LOOK SURGERY
SURGERY AT RELAPSE
COMPLICATIONS OF SURGICAL TREATMENT
Vulval cancer.
SURGERY IN RECURRENT OR ADVANCED DISEASE
6 Role of laparoscopic surgery
Surgical techniques
RADICAL HYSTERECTOMY
Technique
PELVIC LYMPH NODE DISSECTION
LAPAROSCOPIC EXTRAPERITONEAL PARA-AORTIC NODE DISSECTION
7 Radiotherapy: principles and applications
Radiobiology
Planning
Implementation of brachytherapy
IMPORTANCE OF RECTAL AND BLADDER DOSES
DOSE PRESCRIPTION FOR RADIOTHERAPY INCARCINOMA OF THE CERVIX
Adverse effects of radiotherapy
Clinical applications of radiotherapy
CERVICAL CANCER
ENDOMETRIAL CANCER
OVARIAN CANCER
RADIOTHERAPY FOR SYMPTOM CONTROL IN A PALLIATIVE CONTEXT
8 Chemotherapy: principles andapplications
Treatment intent
Toxicity
Epithelial ovarian cancer
EARLY-STAGE OVARIAN CANCER
RECURRENT OVARIAN CANCER
Vulval cancer
Rare tumours
GESTATIONAL TROPHOBLASTIC TUMOURS
NON-EPITHELIAL OVARIAN TUMOURS
9 Ovarian cancer standards of care
Classification of ovarian cancer
EPITHELIAL TUMOURS
GRADE
DISSEMINATION OF THE DISEASE
PRIMARY PERITONEAL TUMOURS
BORDERLINE TUMOURS
NON-EPITHELIAL OVARIAN NEOPLASMS
SEX-CORD STROMAL TUMOURS
MALIGNANT GERM-CELL TUMOURS
Prognostic factors
Presentation and diagnosis
INITIAL ASSESSMENT
IF MALIGNANCY IS SUSPECTED
Referral to the multidisciplinary team
Surgery for ovarian carcinoma
DIAGNOSIS
STAGING
PRIMARY CYTOREDUCTION
OPTIMAL DEBULKING
ULTRARADICAL SURGERY
Lymphadenectomy
CURRENT STANDARD.
Early stage disease, FIGO stage I and IIa epithelial ovarian cancer
Stage IV disease
CURRENT STANDARD
Second-look laparotomy or laparoscopy
Interval debulking surgery
Neoadjuvant chemotherapy followed by surgery
First line chemotherapy for epithelial ovarian cancer
EARLY STAGE DISEASE
Current standard
ADVANCED DISEASE
INTRAPERITONEAL CHEMOTHERAPY
NOVEL CHEMOTHERAPEUTIC AND BIOLOGICAL AGENTS
Management of relapsed disease
THE ROLE OF CHEMOTHERAPY IN RECURRENT DISEASE
Current practice
NOVEL CHEMOTHERAPEUTIC AGENTS
THE ROLE OF SURGERY IN RELAPSED DISEASE
CURRENT PRACTICE
Radiotherapy
Minimal access surgery
Response evaluation
Follow-up
Women with a family history
Screening for ovarian carcinoma
Reference List
10 Endometrial cancer standards of care
Signs and symptoms
Investigation
Surgical management
Radiotherapy and chemotherapy
Palliative treatment and care
Post-treatment support and follow-up
Organisation and provision of services
11 Cervical cancer standards of care
Multidisciplinary team working
Presentation
Diagnosis and staging
OTHER INVESTIGATIONS
Treatment of cervical cancer
STAGE IA
STAGE IB AND IIA
LOCALLY ADVANCED (STAGE IIB AND ABOVE)
EXENTERATIVE SURGERY
Management of recurrent disease
CENTRAL PELVIC RELAPSE
PELVIC SIDE WALL RECURRENCE
DISTANT METASTASES
12 Vulval cancer standards of care
CURRENT STANDARDS
Prevention and predisposing conditions
Referral from primary care
Making the diagnosis
FUNGATING OR ULCERATED MASS
SMALL, WELL CIRCUMSCRIBED MASS
A LESION UNEXPECTEDLY FOUND TO BE CANCEROUS
Biopsy information
HISTOLOGICAL SUBTYPES
Planning treatment
The importance of nodal status
SENTINEL NODE SAMPLING
Staging of vulval cancer
Managing the primary lesion
Managing the lymph nodes
PELVIC NODES
Adjuvant radiotherapy: early disease
INADEQUATE EXCISION MARGIN
POSITIVE LYMPH NODES
Advanced vulval cancer
MANAGEMENT OF GROSSLY INVOLVED NODES
COMBINED TREATMENT FOR THE PRIMARY
Reconstructive surgery
Morbidity
POSTOPERATIVE MORBIDITY
13 Uncommon gynaecological cancers
Gestational trophoblastic disease
FIGO STAGING OF GESTATIONAL TROPHOBLASTIC TUMOURS
PRESENTATION AND DIAGNOSIS
INVESTIGATIONS
MANAGEMENT
FOLLOW-UP AND OUTCOME FOLLOWING CHEMOTHERAPY
Cancer of the fallopian tube
FIGO STAGING OF CARCINOMA OF THE FALLOPIAN TUBE
Laparotomy
Chemotherapy
Radiation
Tubal sarcomas
Nonepithelial ovarian cancers
OVARIAN GERM-CELL TUMOURS
Investigations
DYSGERMINOMAS
Management
Outcome
IMMATURE TERATOMAS
ENDODERMAL SINUS TUMOUR
EMBRYONAL CARCINOMA
POLYEMBRYOMA
CHORIOCARCINOMA OF THE OVARY
MIXED GERM-CELL TUMOURS
OVARIAN SEX-CORD STROMAL CELL TUMOURS
GRANULOSA-STROMAL CELL TUMOURS
GRANULOSA-CELL TUMOURS
Management.
SERTOLI-LEYDIG TUMOURS.
Notes:
Title from publisher's bibliographic system (viewed on 05 Oct 2015).
Includes bibliographical references and index.
ISBN:
1-107-71097-9
1-107-71440-0
1-281-89807-4
1-904752-66-7
9786611898076
1-139-69695-5
OCLC:
769189770

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