Anthraquinones in plants : source, safety and applications in gastrointestinal health / edited by L. Delmulle & K. Demeyer.

Format:

Book

Contributor:

Delmulle, L. (Luc)

Demeyer, K. (Kris)

Language:

English

Subjects (All):

Anthraquinones--Health aspects.

Anthraquinones.

Constipation--Treatment.

Constipation.

Laxatives.

Gastroenterology.

Gastrointestinal system--Microbiology.

Gastrointestinal system.

Physical Description:

1 online resource (173 p.)

Edition:

2nd ed.

Place of Publication:

Nottingham : Nottingham University Press, 2010.

Language Note:

English

Summary:

Unique and informative, this reference reviews the scientific knowledge related to the main plant species used to support gastrointestinal health through their stool-promoting and laxative effects. Botanical, chemical, and clinical aspects are considered in addition to pharmacokinetics, pharmacodynamics, and safety concerns. Discussing a variety of species'including Senna, Rheum, Frangula and Aloe'this account will appeal to academics, physicians, pharmacists, and herbalists.

Contents:

Cover; Anthraquinones in Plants; Copyright ; Table of Contents ; Preface; Introduction; Abbreviations and Definitions; Section 1 Botanical Aspects; Senna/Cassia; Botanical Description and Classification; The Drug; Folium Sennae; Fructus Sennae; Adulterants; Anthranoid Biosynthesis in the Plants and Ontogenic Fluctuations; Geographical Distribution and Cultivation; Use of Related Species; Preparations; Conclusion; References; Rheum (Rhubarb); Botanical Description and Classification; The Drug; Radix Rhei; Anthranoid Biosynthesis in the Plants and Ontogenic Fluctuations

Geographical Distribution and CultivationPreparations; Conclusion; References; Rhamnus; Botanical Description and Classification; The drug; Cortex Frangulae; Cortex Rhamnus purshianae; Anthranoid Biosynthesis in the Plants and Ontogenic Fluctuations; Geographical Distribution and Cultivation; Use of Related Species; Conclusion; References; Aloe; Botanical Description and Classification; The Drug; Aloe vera Gel (Aloe Gel); Aloe (juice); Anthranoid Biosynthesis in the Plants and Ontogenic Fluctuations; Geographical Distribution and Cultivation; Use of Related Species; Conclusion; References

Section 2 Chemistry of 9,10-AnthraquinonesBiosynthesis; Oxidation-reduction and reactivity; Photochemistry; Phenolic characteristics; Analysis; Antioxidant and prooxidant activities; References; Section 3 Pharmacokinetics; Conversion by intestinal bacteria; Conversion of O-glycosyl anthranoids; Conversion of C-glycosyl anthranoids; Influence of the bacterial flora; Systemic absorption, conversion and elimination; Food matrix influences; Conclusion; References; Section 4 Pharmacodynamics and Safety Aspects; Introduction; Types of laxatives and mode of action; Pharmacodynamics of anthranoids

Toxicity studiesPhysiological and morphological aspects; Genotoxicity and mutagenicity; Reproductive toxicity studies; Interactions; Conclusion; References; Section 5 Clinical Aspects; Recommended dose; The use of anthranoid containing plants for constipation; Cassia preparations; Rheum preparations; Rhamnus purshiana preparations; Rhamnus frangula preparations; Aloe preparations; The use of anthranoid-containing plants in cases of irritable bowel syndrome; Senna and Rheum preparations; The use of anthranoid containing plants for bowel cleansing; Senna preparations

Rhamnus purshiana preparationsThe use of anthranoids in paediatrics; Senna preparations; Rheum preparations; The use of anthranoids during pregnancy and lactation; Considerations of the cancerogenic risks of anthranoids; Clinical safety of anthranoid-containing plant species; Absolute contraindications; Relative contraindications; Clinical safety of Senna; Clinical safety of Rheum; Clinical safety of Rhamnus purshiana; Conclusion; References; Section 6 Discussion; Index

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

1-907284-82-6

OCLC:

671648356