Biocatalysis for the pharmaceutical industry : discovery, development, and manufacturing / Junhua Tao, Guoqiang Lin, Andreas Liese.

Format:

Book

Author/Creator:

Tao, Junhua.

Contributor:

Lin, Guoqiang.

Liese, A. (Andreas)

Language:

English

Subjects (All):

Pharmaceutical biotechnology.

Enzymes--Biotechnology.

Enzymes.

Physical Description:

1 online resource (x, 324 pages) : illustrations.

Edition:

1st ed.

Place of Publication:

Singapore ; Hoboken : Wiley, c2009.

Language Note:

English

Summary:

Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

Contents:

1. Enzymes and Their Synthetic Applications: An Overview

2. Expression Hosts for Enzyme Discovery and Production

3. Directed Enzyme Evolution and High-Throughput Screening

4. Applications of Reaction Engineering to Industrial Biotransformations

5. Chiral Synthesis of Pharmaceutical Intermediates Using Oxynitrilases

6. Expanding the Scope of Aldolases as Tools for Organic Synthesis

7. Synthetic Applications of Ketoreductases and Alcohol Oxidases

8. Applications of Nitrile Hydratases and Nitrilases

9. Biosynthesis of Drug Metabolites

10. Application of Whole-Cell Biotransformation in the Pharmaceutical Industry

11. Combinatorial Biosynthesis of Pharmaceutical Natural Products

12. Metabolic Engineering for the Development and Manufacturing of Pharmaceuticals

13. Multimodular Synthases and Supporting Enzymes for Chemical Production

14. Green Chemistry with Biocatalysis for Production of Pharmaceuticals.

Notes:

Includes bibliographical references and index.

ISBN:

9786612382093

9781282382091

1282382098

9780470823163

047082316X

9780470823156

0470823151

OCLC:

441886998

Publisher Number:

9786612382093