Molecular pathology in drug discovery and development / edited by J. Suso Platero.

Format:

Book

Contributor:

Platero, J. Suso.

Language:

English

Subjects (All):

Drug development.

Pathology, Molecular.

Physical Description:

1 online resource (396 p.)

Edition:

1st ed.

Place of Publication:

Hoboken, N.J. : John Wiley, c2009.

Language Note:

English

Summary:

Covers powerful new tools for drug development Molecular pathology offers tools and techniques that can greatly enhance the drug discovery and development process, helping to make the promises of personalized medicine a reality. Molecular Pathology in Drug Discovery and Development provides an unmatched guide to this cutting-edge discipline and its applications to pharmaceutical science. With contributions from leading lights in drug discovery, drug development, and molecular pathology balanced by a consistent editorial approach, this reference offers both an overview of molecular p

Contents:

MOLECULAR PATHOLOGY IN DRUG DISCOVERY AND DEVELOPMENT; CONTENTS; Preface; Contributors; 1 MOLECULAR PATHOLOGY AND DRUG DEVELOPMENT; 1.1. General Pathology; 1.2. General Aspects; 1.3. Molecular Pathology, the Molecular Way; 1.3.1. Loss of Gene Expression; 1.3.2. Translocations; 1.3.3. Detection of Pathogens; 1.3.4. Forensic Identification; 1.3.5. Protein Changes; 1.3.6. Other Methods of Detection; 1.4. Application of Molecular Pathology; 1.5. Molecular Pathology in Drug Development; 1.5.1. Most Important Molecular Pathologic Consideration; 1.6. Pharmaceutical Drug Development

1.6.1. Introduction1.6.2. Drug Discovery and Development; References; 2 MOLECULAR PATHOLOGY IN ONCOLOGY TARGET AND DRUG DISCOVERY; 2.1. Introduction; 2.2. History of Chemotherapy and Cancer Drug Discovery; 2.3. Target-Based Drug Discovery; 2.4. Utilization of Molecular Pathology in the Discovery of Novel Cancer Targets; 2.5. Hit Identification and In Vitro Lead Optimization; 2.6. Implications for Molecular Pathology in Cancer Drug Development and Use; 2.7. Summary and Future Considerations; References; 3 MOLECULAR PATHOLOGY AND TRANSCRIPTIONAL PROFILING IN EARLY DRUG DEVELOPMENT

3.1. Introduction3.2. Biomarkers in Clinical Setting and in Early Drug Development; 3.3. Advantages of Biomarker Implementation; 3.4. Changing Paradigm in Clinical Drug and Biomarker Development; 3.5. Promises of Transcriptional Profiling; 3.6. Biomarker Development and Validation Using Microarray Analysis; 3.7. Neoadjuvant Chemotherapy as an Intriguing Model for Biomarker Development; 3.8. Transcriptional Profiling for Identification of Individual Genes as Biomarkers; 3.9. Transcriptional Profiling for the Definition of Multigene Predictors Using Transcriptional Profiling

3.9.1. Multigene Predictors of Chemotherapy Response3.9.2. Multigene Predictor of Response to a Targeted Therapy Agent; 3.9.3. Novel Approaches to Phase II Clinical Trial Design; 3.10. Novel Tools for Pathway Analysis; 3.11. Implementation of Biomarkers into the Clinical Setting; 3.12. Conclusion; References; 4 MOLECULAR PATHOLOGY IN NONCLINICAL SAFETY ASSESSMENT; 4.1. Introduction; 4.2. Drug Development; 4.2.1. Immunohistochemistry in Drug Development; 4.3. Drug Discovery; 4.3.1. Target Validation and Target-Related Safety Concerns; 4.3.2. Off-Target Effects; 4.4. Biopharmaceuticals

4.5. SummaryReferences; 5 TOXICOGENOMICS IN DRUG DEVELOPMENT; 5.1. Introduction; 5.2. Brief Overview of Large-Scale Gene Expression Technologies; 5.2.1. RNA Quality; 5.2.2. Hybridization Platforms; 5.3. Analysis of Microarray Data; 5.3.1. Normalization and Filtering; 5.3.2. Analyzing for Differences between Experimental Samples; 5.3.3. Familywise Error Rate; 5.3.4. Resampling; 5.3.5. Expression Profile Analysis; 5.3.6. Pathway Analysis; 5.3.7. Gene Expression Databases; 5.3.8. Analyzing Relatedness of Gene Expression Profiles; 5.4. Application of Toxicogenomics in Drug Development

5.4.1. Discovery

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on metadata supplied by the publisher and other sources.

ISBN:

9786612279560

9781282279568

1282279564

9780470475959

0470475951

9780470475942

0470475943

OCLC:

441875028