Essentials of medical genomics / Stuart M. Brown ; with contributions by John G. Hay and Harry Ostrer.

Format:

Book

Author/Creator:

Brown, Stuart M., 1962-

Language:

English

Subjects (All):

Medical genetics.

Genomics.

Physical Description:

1 online resource (466 p.)

Edition:

2nd ed.

Place of Publication:

Hoboken, N.J. : Wiley-Blackwell, c2009.

Language Note:

English

Summary:

Six new chapters on vital topics of interest such as multilocus SNP genotyping (SNP chips), RNAi, ChIP-chip, and genomic tiling arraysNew edition responds to reviewers' and users' desire for greater coverage-now the most useful handbook on the market!Practical, concise summary of everything about genomics and emerging technologies a busy physician or medical student should knowCovers concepts and techniques that are in use in medicine now, as well as those on the cutting-edge of science relevant to medicine, from bioinformatics to DNA diagnostics and proteomicsNEW:</

Contents:

Essentials of Medical Genomics; Contents; Preface; 1 Introduction to Molecular Genetics; The Principles of Inheritance; Genes Are Made of DNA; DNA Structure; The Central Dogma; References; 2 Molecular Biology Technology; Cut, Copy, and Paste; Restriction Enzymes; DNA Cloning Is Copying; PCR Is Cloning without the Bacteria; DNA Sequencing; References; 3 Genome Databases; Genome Sequencing; Entrez; BLAST; Genome Annotation; Genome Browser; Human Genetic Diseases; A System for Naming Genes; Model Organisms (Comparative Genomics); Sequencing Other Genomes; References; 4 Bioinformatics Tools

Patterns and ToolsSequence Comparison; Multiple Alignment; Pattern Finding; Phylogenetics; Biotechnology Exercise; References; 5 Human Genetic Variation; Mutation; Single-Nucleotide Polymorphisms; Linkage; Multigene Diseases; Genetic Testing; SNP Chips; The HapMap Project; Research Uses of SNP Markers; Ethnicity and Genome Diversity; References; 6 Genetic Testing for the Practitioner; Clinical Applications of Genetic Testing; Methods of Genetic Testing; Adequacy of Genetic Testing; Informed Consent; Genetic Counseling; Clinical Vignettes; References; 7 Gene Therapy; Historical Perspective

Strategies of Gene TherapyDNA Elements for Gene Expression; Gene Delivery Systems; Targeting Gene Delivery; Formative Years and Initial Clinical Approaches; The Problems; The Future; References; 8 Microarrays; Spotting versus Synthesis on the Chip; Other Types of Arrays; Differential Gene Expression; Error and Reliability; Evolutionary Perspectives; References; 9 Analysis of Microarray Data; Experimental Design; Data Analysis Workflow; Functional Analysis; Validation; References; 10 Pharmacogenomics and Toxicogenomics; Pharmacogenomics; Environmental Chemicals

Toxicogenomics for Drug DevelopmentReferences; 11 Clinical Research Informatics; Clinical Databases; Clinical Trials Management; Data Standards and Ontologies; Tissue Banks; Application to Medical Practice; References; 12 RNA Interference and MicroRNAs; Antisense RNA; RNA Interference; Ribozymes; References; 13 Alternative Splicing; Exon Arrays; Medical Applications of Alternative Splicing; References; 14 Genome Tiling Chips; Genome Chips; Resequencing Chips; Whole-Genome Transcription Profiling; ChIP-chip; ArrayCGH; References; 15 Cancer Genomics; Understanding Cancer Genomics

Copy Number MutationsGene Expression Signatures; Cancer Genome Atlas; References; 16 Proteomics; Protein Modifications; Quantitative Approaches; Biomarkers; Protein Databases; Protein-Protein Interactions; DNA-Binding Proteins; Structural Proteomics; Drug Targets; References; 17 Consumer Genomics and Genealogy; Genealogy; Nutrigenomics; Privacy Concerns; References; 18 The Ethics of Medical Genomics; Eugenics; Human Genome Diversity Project and Population Genetics; Genetic Discrimination; Impact on Physicians and Researchers; Clinical Research; References

Appendix: Genetic Testing: Scientific Background for Policymakers

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on metadata supplied by the publisher and other sources.

ISBN:

9780470334492

0470334495

9781282003552

1282003550

9780470336168

0470336161

OCLC:

646799824