Translational control of gene expression / edited by Nahum Sonenberg, John W.B. Hershey, Michael B. Mathews.

Format:

Book

Contributor:

Sonenberg, Nahum.

Hershey, John W. B.

Mathews, Michael.

Series:

Cold Spring Harbor monograph series ; 39.

Cold Spring Harbor monograph series ; 39

Language:

English

Subjects (All):

Genetic translation.

Physical Description:

x, 1020 p. : ill. (some col.).

Edition:

2nd ed.

Place of Publication:

Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press, c2000.

Summary:

This new monograph updates and expands the scope of a 1996 publication and also takes a fresh look at the field. The first eight chapters provide broad overviews, and the additional 28 focus on research topics of more specific interest, thus providing an up-to- date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translational machinery of virus infection and disease. Contains a few color illustrations. Annotation copyrighted by Book News, Inc., Portland, OR

Contents:

Intro

Contents

Preface

Origins and Principles of Translational Control

The Pathway and Mechanism of Initiation of Protein Synthesis

The Protein Biosynthesis Elongation Cycle

A Comparative View of Initiation Site Selection Mechanisms

Mechanism and Regulation of Initiator Methionyl- tRNA Binding to Ribosomes

Regulation of Ribosomal Recruitment in Eukaryotes

Translational Control of Developmental Decisions

Viral Translational Strategies and Host Defense Mechanisms

Ribosomal Subunit Joining

Physical and Functional Interactions between the mRNA Cap Structure and the Poly( A) Tail

Translation Termination: ItÌs Not the End of the Story

Genetic Approaches to Translation Initiation in Saccharomyces cerevisiae

The Double-stranded RNA-activated Protein Kinase PKR

Heme-regulated eIF2 Kinase

PERK and Translational Control by Stress in the Endoplasmic Reticulum

Regulation of Translation Initiation in Mammalian Cells by Amino Acids

Translational Control during Heat Shock

Translational Control by Upstream Open Reading Frames

Cellular Internal Ribosome Entry Site Elements and the Use of cDNA Microarrays in Their Investigation

Translational Control and Cancer

Translational Control of Ferritin Synthesis

Translational Control of TOP mRNAs

S6 Phosphorylation and Signal Transduction

Control of the Elongation Phase of Protein Synthesis

Programmed Translational Frameshifting, Hopping, and Readthrough of TerminationCodons

Recoding UGA as Selenocysteine

Influence of Polyadenylation-induced Translation on Metazoan Development and Neuronal Synaptic Function

Interaction of mRNA Translation and mRNA Degradation in Saccharomyces cerevisiae

Destabilization of Nonsense-containing Transcripts in Saccharomyces cerevisiae.

Nonsense-mediated RNA Decay in Mammalian Cells: A Splicing- dependent Means to Down- regulate the Levels of mRNAs That Prematurely Terminate Translation

Translation Initiation on Picornavirus RNA

Adenovirus Inhibition of Cellular Protein Synthesis and Preferential Translation of Viral mRNAs

Reovirus Translational Control

Translational Reprogramming during Influenza Virus Infection

Translational Control in Poxvirus- infected Cells

Nontranslational Functions of Components of the Translational Apparatus

Index.

Notes:

Includes bibliographical references and index.

ISBN:

0-87969-676-1

OCLC:

932350507