Epigenetics : linking genotype and phenotype in development and evolution / edited by Benedikt Hallgrimsson and Brian K. Hall.

Format:

Book

Contributor:

Hallgrímsson, Benedikt..

Hall, Brian K.. (Brian Keith), 1941-

Language:

English

Subjects (All):

Phenotype.

Epigenesis.

Genotype-environment interaction.

Genetic regulation.

Developmental genetics.

Evolutionary genetics.

Physical Description:

1 online resource (469 p.)

Edition:

1版.

Place of Publication:

Berkeley : University of California Press, c2011.

Language Note:

English

Summary:

Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in development, disease, and evolution. Chapters cover such topics as morphogenesis and organ formation, conceptual foundations, and cell differentiation, and together demonstrate that the integration of epigenetics into mainstream developmental biology is essential for answering fundamental questions about how phenotypic traits are produced.

Contents:

Frontmatter

Contents

Contributors

1. Introduction

2. A Brief History of the Term and Concept Epigenetics

3. Heuristic Reductionism and the Relative significance of Epigenetic Inheritance in evolution

4. The Epigenetics of Genomic Imprinting: Core Epigenetic Processes are conserved in Mammals, Insects, and Plants

5. Methylation Mapping in Humans

6. Asexuality and Epigenetic Variation

7. Epigenesis, Preformation, and the Humpty Dumpty Problem

8. A Principle of Developmental Inertia

9. The Role of Epigenetics in Nervous System Development

10. Morphogenesis of Pigment Patterns: Experimental and Modeling Approaches

11. Epigenetic Interactions of the Cardiac Neural Crest

12. Epigenetics in Bone and cartilage Development

13. Muscle-Bone Interactions and the Development of skeletal Phenotype: Jaw muscles and the skull

14. Evolution of the Apical Ectoderm in the Developing Vertebrate Limb

15. Role of Skeletal Muscle in the Epigenetic Shaping of Organs, Tissues, and Cell Fate Choices

16. Epigenetic Integration, Complexity, and Evolvability of the Head: Rethinking the Functional Matrix Hypothesis

17. Epigenetic Interactions: The Developmental Route to Functional Integration

18. Epigenetic Contributions to Adaptive Radiation: Insights from Threespine Stickleback

19. Learning, Developmental Plasticity, and the Rate of Morphological Evolution

20. Epigenetics: Adaptation or Contingency?

21. The Epigenetics of Dysmorphology. Craniosynostosis as an Example

22. Epigenetics of Human Disease

23. Epigenetics: The Context of Development

Index

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

ISBN:

9786613331854

9781283331852

1283331853

9780520948822

0520948823

OCLC:

719319907