Induction and analysis of antigen-specific T cell responses in melanoma patients and animal models / Adriaan Dirk Bins.

Format:

Book

Author/Creator:

Bins, Adriaan Dirk.

Language:

English

Subjects (All):

Melanoma--Immunological aspects--Research.

Melanoma.

Immunocompetent cells--Research.

Immunocompetent cells.

T cells--Research.

T cells.

Cancer vaccines--Research.

Cancer vaccines.

Physical Description:

1 online resource (149 p.)

Edition:

2nd ed.

Place of Publication:

Leiden : Leiden University Press, c2008.

Language Note:

English

Summary:

In the last century, it has become clear that in patients suffering certain types of cancer, spontaneous activation of the immune system may lead to curation. The concept of immunotherapy is based on that notion. The intention is to stimulate T cells direc

Contents:

Contents; Introduction; Ch.1: On the Role of Melanoma-Specific CD8+ T-Cell Immunity in Disease Progression of Advanced-Stage Melanoma Patients.; Ch.2:Phase I clinical study with multiple peptide vaccines in combination with tetanus toxoid and GM-CSF in advanced-stage HLA-A*0201- positive melanoma patients.; Ch.3: A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression; Ch.4:Superior immunogenicity of DNA tattooing as compared to intramuscular DNA vaccination in non-human primates.; Ch.5: In vivo antigen stability affects vaccine efficacy

Ch.6: Intravital imaging of fluorescent markers and FRET probes by DNA tattooing.Ch.7: Design and use of conditional MHC class I ligands; Discussion; Dutch Summary; Acknowledgements and Curriculum Vitae

Notes:

Description based upon print version of record.

Includes bibliographical references.

ISBN:

1-281-78780-9

9786611787806

90-485-0591-7

OCLC:

476251043