Molybdenum-99 for medical imaging / Nuclear and Radiation Studies Board Division on Earth and Life Studies.

Format:

Book

Author/Creator:

Nuclear and Radiation Studies Board Division on Earth and Life Studies.

Language:

English

Subjects (All):

Diagnostic imaging.

Molybdenum--Isotopes.

Molybdenum.

Physical Description:

1 online resource (264 pages) : illustrations, tables

Place of Publication:

Washington, District of Columbia : National Academies Press, 2016.

Summary:

The decay product of the medical isotope molybdenum-99 (Mo-99), technetium-99m (Tc-99m), and associated medical isotopes iodine-131 (I-131) and xenon-133 (Xe-133) are used worldwide for medical diagnostic imaging or therapy. The United States consumes about half of the world's supply of Mo-99, but there has been no domestic (i.e., U.S.-based) production of this isotope since the late 1980s. The United States imports Mo-99 for domestic use from Australia, Canada, Europe, and South Africa. Mo-99 and Tc-99m cannot be stockpiled for use because of their short half-lives. Consequently, they must be routinely produced and delivered to medical imaging centers. Almost all Mo-99 for medical use is produced by irradiating highly enriched uranium (HEU) targets in research reactors, several of which are over 50 years old and are approaching the end of their operating lives. Unanticipated and extended shutdowns of some of these old reactors have resulted in severe Mo-99 supply shortages in the United States and other countries. Some of these shortages have disrupted the delivery of medical care. Molybdenum-99 for Medical Imaging examines the production and utilization of Mo-99 and associated medical isotopes, and provides recommendations for medical use.

Contents:

Executive summary

Summary

Background and study tasks

Medical isotope production and utilization

Global production of molybdenum-99 and future prospects

Progress toward establishing domestic production of molybdenum-99 and associated medical isotopes

Progress in eliminating highly enriched uranium and remaining obstacles

Molybdenum-99/technetium-99m historic and projected demand

Molybdenum-99/technetium-99m supply

References

Appendix A: The American Medical Isotopes Production Act of 2012

Appendix B: Committee and staff biographies

Appendix C: Presentations and site visits

Appendix D: List of radiopharmaceuticals and associated codes used in the Committee's medicare data and nuclear pharmacy data analyses

Appendix E: Acronyms.

Notes:

Description based on online resource; title from PDF title page (ebrary, viewed November 24, 2016).

ISBN:

9780309445344

0309445345

9780309445320

0309445329