Application of modern toxicology approaches for predicting acute toxicity for chemical defense / Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures [and four others].

Format:

Book

Author/Creator:

National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures, author.

Contributor:

National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures, author.

Language:

English

Subjects (All):

Chemical warfare--United States--Safety measures.

Chemical warfare.

Toxicology--Research--United States.

Toxicology.

United States.

Medical Subjects:

United States.

Physical Description:

1 online resource (134 p.)

Place of Publication:

Washington, District of Columbia : The National Academies Press, 2015.

Language Note:

English

Summary:

The US Department of Defense (DOD) is faced with an overwhelming task in evaluating chemicals that could potentially pose a threat to its deployed personnel. There are over 84,000 registered chemicals, and testing them with traditional toxicity-testing methods is not feasible in terms of time or money. In recent years, there has been a concerted effort to develop new approaches to toxicity testing that incorporate advances in systems biology, toxicogenomics, bioinformatics, and computational toxicology. Given the advances, DOD asked the National Research Council to determine how DOD could use modern approaches for predicting chemical toxicity in its efforts to prevent debilitating, acute exposures to deployed personnel. This report provides an overall conceptual approach that DOD could use to develop a predictive toxicology system. "Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense" reviews the current state of computational and high-throughput approaches for predicting acute toxicity and suggests methods for integrating data and predictions. This report concludes with lessons learned from current high-throughput screening programs and suggests some initial steps for DOD investment.

Contents:

FrontMatter; Preface; Contents; Application of Modern Toxicology Approaches for Predicting Acute Toxicity for Chemical Defense; Summary; 1 Introduction; 2 Conceptual Framework and Prioritization Strategy; 3 Nontesting Approaches Relevant to Prediction of Acute Toxicity and Potency; 4 Assays for Predicting Acute Toxicity; 5 Integration and Decision-Making for Predictive Toxicology; 6 Lessons Learned and Next Steps; Appendix A: Biographical Information on the Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures; Appendix B: Available Data or Databases

Notes:

Description based upon print version of record.

Includes bibliographical references at the end of each chapters.

Description based on online resource; title from PDF title page (ebrary, viewed March 17, 2016).

ISBN:

0-309-37667-X

OCLC:

921843482