Application of toxicogenomics to cross-species extrapolation : report of a workshop / Committee on Applications of Toxicogenomics to Cross-Species Extrapolation.

Format:

Book

Contributor:

National Research Council (U.S.). Committee on Applications of Toxicogenomics to Cross-Species Extrapolation.

Language:

English

Subjects (All):

Toxicology.

Environmental sciences.

Physical Description:

1 online resource (58 p.)

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academies Press, c2006.

Language Note:

English

Summary:

Some of what we know about the health effects of exposure to chemicals from food, drugs, and the environment come from studies of occupational, inadvertent, or accident-related exposures. When there is not enough human data, scientists rely on animal data to assess risk from chemical exposure and make health and safety decisions. However, humans and animals can respond differently to chemicals, including the types of adverse effects experienced and the dosages at which they occur. Scientists in the field of toxicogenomics are using new technologies to study the effects of chemicals. For example, in response to a particular chemical exposure, they can study gene expression ("transcriptomics"), proteins ("proteomics") and metabolites ("metabolomics"), and they can also look at how individual and species differences in the underlying DNA sequence itself can result in different responses to the environment. Based on a workshop held in August 2004, this report explores how toxicogenomics could enhance scientists' ability to make connections between data from experimental animal studies and human health.

Contents:

""Front matter""; ""Preface""; ""Contents""; ""Summary of the Workshop""; ""References""; ""Appendix A""; ""Appendix B""; ""Appendix C""

Notes:

Description based upon print version of record.

ISBN:

9786610447466

9780309181686

0309181682

9781280447464

128044746X

9780309656139

0309656133

OCLC:

923275316