Review of the HIVNET 012 perinatal HIV prevention study / Committee on Reviewing the HIVNET 012 Perinatal HIV Prevention Study, Board on Population Health and Public Health Practice, Institute of Medicine of the National Academies.

Format:

Book

Contributor:

Institute of Medicine (U.S.). Committee on Reviewing the HIVNET 012 Perinatal HIV Prevention Study.

Language:

English

Subjects (All):

HIV infections--Prevention.

HIV infections.

HIV infections--Transmission.

Perinatology.

Physical Description:

1 online resource (149 p.)

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academies Press, c2005.

Language Note:

English

Summary:

Mother-to-child transmission of HIV-1 afflicts hundreds of thousands of children every year, especially in parts of the world such as sub-Saharan Africa, where HIV infection is prevalent and resources are limited. This tragic reality has spurred researchers to search for an effective, safe, and inexpensive treatment that could reduce the risk of perinatal HIV transmission. The HIVNET 012 trial was designed to provide preliminary information on the comparative safety and efficacy of two relatively simple and inexpensive short courses of oral antiretroviral treatment likely to be feasible in resource-limited settings. The resulting report identified some problems with procedures and documentation, but concluded that these issues did not compromise the results of the study. However, these issues have led to public scrutiny and continued controversy. Review of the HIVNET 012 Perinatal HIV Prevention Study critically and objectively evaluates the study's design and conduct, and assesses the impact of the initial procedural issues on the validity of the overall findings and conclusions of the trial.

Contents:

""Front Matter""; ""Reviewers""; ""Foreword""; ""Contents""; ""Executive Summary""; ""1 Introduction""; ""2 Overview of HIVNET 012""; ""3 Study Design, Treatment Assignment, and Adherence to Study Regimens""; ""4 Efficacy and Safety""; ""5 Review of Ethical Issues""; ""6 Response to the Charge to the Committee""; ""Appendixes""; ""Appendix A Agendas of Information-Gathering Meetings""; ""Appendix B Comparisons to Other Perinatal HIV Prevention Studies Using NVP and ZDV""; ""Appendix C Committee Biographies""

Notes:

Description based upon print version of record.

Includes bibliographical references.

ISBN:

9786612083389

9780309181433

0309181437

9781282083387

1282083384

9780309550123

0309550122

OCLC:

923274892