Overcoming challenges to develop countermeasures against aerosolized bioterrorism agents : appropriate use of animal models / Committee on Animal Models for Testing Interventions Against Aerosolized Bioterrorism Agents, Board on Life Sciences, Institute for Laboratory Animal Research, Division of Earth and Life Studies.

Format:

Book

Contributor:

National Research Council (U.S.). Committee on Animal Models for Testing Interventions Against Aerosolized Bioterrorism Agents.

National Research Council (U.S.). Board on Life Sciences.

Institute for Laboratory Animal Research (U.S.)

Language:

English

Subjects (All):

Bioterrorism--Research.

Bioterrorism.

Chemical warfare.

Physical Description:

1 online resource (88 p.)

Edition:

1st ed.

Place of Publication:

Washington D.C. : The National Academies Press, c2006.

Language Note:

English

Summary:

The National Institute of Allergy and Infectious Diseases (NIAID) gives the highest priority to developing countermeasures against bioterrorism agents that are highly infective when dispersed in aerosol form. Developing drugs to prevent or treat illnesses caused by bioterrorism agents requires testing their effectiveness in animals since human clinical trials would be unethical. At the request of NIAID, the National Academies conducted a study to examine how such testing could be improved. Overcoming Challenges to Develop Countermeasures Against Aerosolized Bioterrorism Agents provides recommendations to researchers on selecting the kinds of animal models, aerosol generators, and bioterrorism agent doses that would produce conditions that most closely mimic the disease process in humans. It also urges researchers to fully document experimental parameters in the literature so that studies can be reproduced and compared. The book recommends that all unclassified data on bioterrorism agent studies--including unclassified, unpublished data from U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID)--be published in the open literature. The book also calls on the U.S. Food and Drug Administration to improve the process by which bioterrorism countermeasures are approved based on the results of animal studies.

Contents:

""Front Matter""; ""Preface""; ""Contents""; ""Glossary""; ""Summary""; ""1 Introduction""; ""2 Selection or Development of an Animal Model""; ""3 Generation and Characterization of Aerosolized Agents""; ""4 Dosimetry Considerations""; ""5 Experimental Design""; ""6 Resource Issues""; ""References""; ""About the Authors""; ""Appendix A: Public Workshop Agenda, and Biographical Information about the Speakers,""

Notes:

Description based upon print version of record.

Includes bibliographical references.

ISBN:

9786610567409

9780309180900

0309180902

9781280567407

1280567406

9780309660938

0309660939

OCLC:

923276964