Translational pain research : from mouse to man / edited by Lawrence Kruger, Alan R. Light.

Format:

Book

Contributor:

Kruger, Lawrence.

Light, Alan R., 1950-

Series:

Frontiers in neuroscience (Boca Raton, Fla.)

Frontiers in neuroscience

Language:

English

Subjects (All):

Pain--Pathophysiology.

Pain.

Mice as laboratory animals.

Physical Description:

1 online resource (458 p.)

Edition:

1st ed.

Place of Publication:

Boca Raton, FL : CRC Press/Taylor & Francis, c2010.

Language Note:

English

Summary:

One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with

Contents:

Painful multi-symptom disorders : a systems perspective / C. Richard Chapman

Neurotrophic factors and nociceptor sensitization / Michael P. Jankowski and H. Richard Koerber

The role of visceral afferents in disease / Julie A. Christianson and Brian M. Davis

Cancer pain : from the development of mouse models to human clinical trials / Juan Miguel Jimenez Andrade and Patrick Mantyh

Therapeutic targeting of peripheral cannabinoid receptors in inflammatory and neuropathic pain states / Igor Spigelman

Molecular strategies for therapeutic targeting of primary sensory neurons in chronic pain syndromes / Ichiro Nishimura ... [et al.]

Transgenic mouse models for the tracing of "pain" pathways / Allan I. Basbaum and Joao M. Braz

Cytokines in pain / Veronica I. Shubayev, Kinshi Kato, and Robert R. Myers

Glial modulation in pain states : translation into humans / Ryan J. Horvath, Edgar Alfonso Romero-Sandoval, and Joyce A. De Leo

On the role of ATP-gated P2X receptors in acute, inflammatory, and neuropathic pain / Estelle Toulme ... [et al.]

Myalgia and fatigue : translation from mouse sensory neurons to fibromyalgia and chronic fatigue syndromes / Alan R. Light, Charles J. Vierck, and Kathleen C. Light

Reflex autonomic responses evoked by group III and IV muscle afferents / Jennifer L. McCord and Marc P. Kaufman

Central pain as a thalamocortical dysrhythmia : a thalamic efference disconnection? / Kerry D. Walton and Rodolfo R. Llinas

What can neuroimaging tell us about central pain? / D.S. Veldhuijzen ... [et al.]

Human brain imaging studies of chronic pain : translational opportunities / A. Vania Apkarian

Consideration of pharmacokinetic pharmacodynamic relationships in the discovery of new pain drugs / Garth T. Whiteside and Jeffrey D. Kennedy

Large animal models for pain therapeutic development / Darrell A. Henze and Mark O. Urban

Drug discovery and development for pain / Sandra R. Chaplan, William A. Eckert III, and Nicholas I. Carruthers.

Notes:

Description based upon print version of record.

Includes bibliographical references and index.

Description based on metadata supplied by the publisher and other sources.

ISBN:

1-4398-5931-0

0-429-13135-6

1-138-11604-1

1-4398-1210-1

9780429131356

OCLC:

671655575