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Neurobiology of Huntington's disease : applications to drug discovery / edited by Donald C. Lo and Robert E. Hughes.
- Format:
- Book
- Series:
- Frontiers in neuroscience (Boca Raton, Fla.)
- Frontiers in neuroscience
- Language:
- English
- Subjects (All):
- Huntington's disease--Pathophysiology.
- Huntington's disease.
- Huntington's disease--Molelcular aspects.
- Neuropharmacology.
- Physical Description:
- 1 online resource (342 p.)
- Edition:
- 1st ed.
- Place of Publication:
- Boca Raton : CRC Press/Taylor & Francis Group, 2010.
- Language Note:
- English
- Summary:
- In 1993, the genetic mutation responsible for Huntington's disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington's Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this
- Contents:
- ch. 1. Huntington's disease : clinical features and routes to therapy / Henry L. Paulson and Roger L. Albin
- ch. 2. Huntington's disease pathogenesis : mechanisms and pathways / Albert R. La Spada, Patrick Weydt, and Victor V. Pineda
- ch. 3. Protein interactions and target discovery in HD / John P. Miller and Robert E. Hughes
- ch. 4. Target validation for Huntington's disease / Seung P. Kwak, James K.T. Wang, and David S. Howland
- ch. 5. High-throughput and high-content screening for Huntington's disease therapeutics / Hemant Varma, Donald C. Lo, and Brent R. Stockwell
- ch. 6. Value of invertebrate genetics and biology to develop neuroprotective and preventive medicine in Huntington's disease / Christian Neri
- ch. 7. Mouse models for validating preclinical candidates for HD / X. William Yang and Michelle Gray
- ch. 8. Pharmaceutical development for HD / Richard J. Morse ... [et al.]
- ch. 9. RNA and DNA-based therapies for Huntington's disease / Meghan Sass and Neil Aronin
- ch. 10. Recombinant intrabodies as molecular tools and potential therapeutics for Huntington's disease / Ali Khoshnan ... [et al.]
- ch. 11. Biomarkers to enable the development of neuroprotective therapies for Huntington's disease / Steven M. Hersch and H. Diana Rosas
- ch. 12. Huntington disease : clinical experimental therapeutics / Ray Dorsey and Ira Shoulson.
- Notes:
- Description based upon print version of record.
- Includes bibliographical references and index.
- Description based on print version record.
- ISBN:
- 9781040200803
- 104020080X
- 9781138116627
- 1138116629
- 9780429122255
- 042912225X
- 9781420008258
- 1420008250
- OCLC:
- 677994381
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