Amyloid-beta clearance in Alzheimer's disease / topic editors: Robert A. Marr and Eliezer Masliah.

Format:

Book

Author/Creator:

Robert Marr

Contributor:

Eliezer Masliah

Series:

Frontiers in aging neuroscience.

Frontiers research topics

Frontiers in aging neuroscience

Language:

English

Subjects (All):

Alzheimer's disease.

Alzheimer's disease--Pathogenesis.

Alzheimer's disease--Molecular aspects.

Neurosciences.

Physical Description:

1 online resource (111 pages) : illustrations; digital, PDF file(s).

Place of Publication:

Frontiers Media SA 2015

[Place of publication not identified] : Frontiers Media SA, 2015.

Language Note:

English

System Details:

text file PDF

Summary:

Strong evidence continues to accumulate indicating that amyloid-beta (Aβ) is a central part of Alzheimer’s disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aβ are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aβ clearance in AD. The topics covered include proteases that degrade Aβ and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed.

Notes:

Includes bibliographical references.

Description based on e-publication, viewed on July 24, 2018.

Access Restriction:

Open access Unrestricted online access