Animal model studies on viral infections / Topic editors: Akio Adachi and Tomoyuki Miura.

Format:

Book

Author/Creator:

Tomoyuki Miura

Contributor:

Adachi, Akio, editor.

Miura, Tomoyuki, editor.

Series:

Frontiers in microbiology.

Frontiers research topics

Frontiers in microbiology

Language:

English

Subjects (All):

Microbiology.

Virus diseases--Pathogenesis.

Virus diseases.

Virology--Research.

Virology.

Physical Description:

1 online resource (173 pages) : illustrations; digital, PDF file(s).

Place of Publication:

Frontiers Media SA 2015

[Place of publication not identified] : Frontiers Media SA, 2015.

Language Note:

English

System Details:

text file PDF

Summary:

Understanding viral replication and pathogenicity properties in infected individuals is a major mission of animal virology. Animal models are essential to analyze the in vivo viral characteristics and to develop countermeasures against viruses. To fight against a wide variety of viruses, basic studies with specific and/ or common approaches are required. This Research Topic collects articles that describe studies on numerous virus species at various stages toward animal experiments: (i) description/evaluation/ new challenges of animal model studies; (ii) experimental material/methods for animal model studies; (iii) observations for upcoming animal model studies. Numbers of DNA and RNA viruses such as HHV-6, HPV, Ebola virus, HCV, dengue virus, HTLV-1, HIV-1, SIV, and measles virus are covered by this special issue consisting of original research, methods, review, mini-review, and opinion articles. All readers would understand, we believe and hope, that animal model studies are critical for current virology as always.

Contents:

Animal model studies on viral infections

Animal models for human Herpesvirus 6 infection

Animal models for Ebola and Marburg virus infections

Hepatitis C virus infection and related liver disease: the quest for the best animal model

Can non-human primates serve as models for investigating Dengue disease pathogenesis?

A transgenic mouse model of human T cell Leukemia virus type-1 associated diseases

Mechanisms of pathogenesis induced by bovine leukemia virus as a model for human T-cell leukemia virus

Macaques as model hosts for studies of HIV-1 infection

Macaque-tropic Human Immunodeficiency Virus type 1: breaking out of the host restriction factors

Genetic similarity of circulating and small intestinal virus at the end stage of acute pathogenic Simian-Human Immunodeficiency Virus infection

A novel but simple method for generation of human dendritic cells from unfractionated peripheral blood mononuclear cells within 2 days: its application for induction of HIV-1-reactive CD4⁺ T cells in the hu-PBL SCID mice

Growth potentials of CCR5-Tropic/CXCR4-Tropic HIV-1mt clones in macaque cells

Sensitive detection of measles virus infection in the blood and tissues of humanized mouse by one-step quantitative RT-PCR

Quantification of viral infection dynamics in animal experiments

Transgenic expression of the human LEDGF/p75 gene relieves the species barrier against HIV-1 infection in mouse cells

Increased infectivity in human cells and resistant to antibody-mediated neutralization by truncation of the SIV gp41 cytoplasmic tail

Natural infection of murine novovirus in conventional and specific pathogen free laboratory mice

HPV18 E1̂ˆ̂E4 is assembled into aggresome-like compartment and involved in sequestration of viral oncoproteins.

Notes:

Includes bibliographical references.

Description based on e-publication, viewed on July 12, 2018.

Access Restriction:

Open access Unrestricted online access