Histamine H4 receptor : a novel drug target for immunoregulation and inflammation / Holger Stark.

Format:

Book

Author/Creator:

Stark, Holger, author.

Series:

Versita discipline : Chemistry, Life Sciences

Language:

English

Subjects (All):

Histamine.

Physical Description:

1 online resource (368 pages) : illustrations; digital, PDF file(s).

Edition:

1st ed.

Place of Publication:

London, England : Versita, Versita Limited, 2013.

Language Note:

English

System Details:

text file

Summary:

H4 R is the newest member of the histamine receptor family, which was discovered about twelve years ago. It is considered a very promising drug target. The effort to improve the pharmacokinetic properties of the currently available H4 R ligands is reflected in a steadily growing number of scientific publications and patent applications. Preclinical data strongly confirms the need for novel potent H4 R ligands to explore their therapeutic value in allergy, inflammation, autoimmune disorders, and possibly, cancer. Readers will be provided with extensive knowledge on histamine metabolism, as well as cellular histamine transport, storage and release, effects of histamine and histamine receptor ligands, with particular attention to the H4 R, on inflammatory cells including mast cells, basophils, eosinophils, neutrophils, macrophages, dendritic cells, and T cells. The present knowledge on the regulatory role of histamine and the therapeutic exploitation of histamine receptor ligands in atopic diseases, with emphasis on human and animal models of asthma, allergic dermatitis and pruritus are discussed.

Contents:

Front matter

Contents

Preface

Chapter 1 The histamine H4 receptor story

Chapter 2 Histamine H4 Receptor Ligands

Chapter 3 Histamine Metabolism

Chapter 4 Histamine Receptors and Inflammatory Cells

Chapter 5 Histamine in Asthmatic and Fibrotic Lung Disorders

Chapter 6 Histamine in Atopic Disorders: Atopic Dermatitis and Pruritus

Chapter 7 Non-professional Histamine Producing Cells, Immune Responses and Autoimmunity

Chapter 8 Histamine in Cancer

Chapter 9 Non Receptor-mediated Histamine Actions

Chapter 10 Perspectives in H4R Research and Therapeutic Exploitation

List of Figures

List of Tables

Index

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references and index.

This eBook is made available Open Access. Unless otherwise specified individually in the content, the work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND) license: https://creativecommons.org/licenses/by-nc-nd/3.0 https://www.degruyter.com/dg/page/open-access-policy

Description based on online resource; title from PDF title page (ebrary, viewed May 28, 2015).

OCLC:

1013942220