Responsible research : a systems approach to protecting research participants / Daniel D. Federman, Kathi E. Hanna, and Laura Lyman Rodriguez, editors ; Committee on Assessing the System for Protecting Human Research Participants.

Format:

Book

Contributor:

Federman, Daniel D., 1928-2017.

Hanna, Kathi E.

Rodriguez, Laura Lyman.

Institute of Medicine (U.S.). Committee on Assessing the System for Protecting Human Research Participants.

Language:

English

Subjects (All):

Human experimentation in medicine--Moral and ethical aspects.

Human experimentation in medicine.

Medical ethics.

Medical protocols.

Patients--Legal status, laws, etc.

Patients.

Physical Description:

1 online resource (312 p.)

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academies Press, c2003.

Language Note:

English

Summary:

When 18-year-old Jesse Gelsinger died in a gene transfer study at the University of Pennsylvania, the national spotlight focused on the procedures used to ensure research participants (TM) safety and their capacity to safeguard the well-being of those who volunteer for research studies. Responsible Research outlines a three-pronged approach to ensure the protection of every participant through the establishment of effective Human Research Participant Protection Programs (HRPPPs). The approach includes: Improved research review processes, Recognition and integration of research participants (TM) contributions to the system, and Vigilant maintenance of HRPPP performance. Issues addressed in the book include the need for in-depth, complimentary reviews of science, ethics, and conflict of interest reviews; desired qualifications for investigators and reviewers; the process of informed consent; federal and institutional oversight; and the role of accreditation. Recommendations for areas of key interest include suggestions for legislative approaches, compensation for research-related injury, and the refocusing of the mission of institutional review boards. Responsible Research will be important to anyone interested in the issues that are relevant to the practice of using human subjects as research participants, but especially so to policy makers, research administrators, investigators, and research sponsors " but also including volunteers who may agree to serve as research participants.

Contents:

Front Matter

Preface

Reviewers

Acknowledgments

Acronyms

Contents

List of Tables, Figures, and Boxes

Executive Summary

1 Introduction

2 A Systemic Approach to Human Research Participant Protection Programs

3 Back to Basics: Scientific, Conflict of Interest, and Ethical Review of Research Protocols

4 The Participant-Investigator Interface

5 Improving Protection Through Oversight and Data and Safety Monitoring

6 Improving Human Research Participant Protection Program Performance and Clarifying Roles

7 Improving an Evolving National Human Research Participant Protection System

References

Appendix A Data Sources and Methods

Appendix B

Appendix C Clarifying Protocol Accountability

Appendix D Committee Biographies

Index.

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references and index.

ISBN:

9786610209392

9780309169035

0309169038

9781280209390

1280209399

9780309500463

030950046X

OCLC:

52817279