Self-perpetuating structural states in biology, disease, and genetics.

Format:

Book

Conference/Event

Author/Creator:

Proceedings of the National Academy of Sciences, Corporate Author.

Conference Name:

Sackler Colloquium on Self-Perpetuating Structural States in Biology, Disease, and Genetics (2002 : Washington, D.C.)

Arthur M. Sackler Colloquia of the National Academy of Sciences (2002 : Irvine, Calif.)

Language:

English

Subjects (All):

Biology--Congresses.

Biology.

Proteins--Conformation--Congresses.

Proteins.

Physical Description:

1 online resource (140 p.)

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academy of Sciences, c2002.

Language Note:

English

Contents:

Self-Perpetuating Structural States in Biology, Disease, and Genetics

Copyright

Contents

Colloquium Self-perpetuating structural states in biology, disease, and genetics

Colloquium Transmission of prions

"NATURAL" TRANSMISSION OF PRIONS

IATROGENIC TRANSMISSION OF PRIONS

EXPERIMENTAL TRANSMISSION OF SURFACE-BOUND PRIONS

CONCLUDING REMARKS

Colloquium Conservation of a portion of the S.cerevisiae Ure2p prion domain that interacts with the full-length protein

MATERIALS AND METHODS

RESULTS

DISCUSSION

Colloquium Interactions among prions and prion "strains" in yeast

Colloquium Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington's disease by…

Colloquium Chaperoning brain degeneration

A DROSOPHILA MODEL FOR HUMAN NEURODEGENERATIVE DISEASE

THE MOLECULAR CHAPERONE HSP70 IS A POTENT SUPPRESSOR OF POLYGLUTAMINE PATHOGENICITY

CHAPERONE SUPPRESSION OF Α-SYNUCLEIN TOXICITY IN A DROSOPHILA MODEL FOR PARKINSON'S DISEASE

ENDOGENOUS CHAPERONE ACTIVITY PLAYS A ROLE IN -SYNUCLEIN TOXICITY IN DROSOPHILA AND POTENTIALLY ALSO IN PARKINSON'S DISEASE

Colloquium Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity

MECHANISM OF POLYQ AGGREGATION

RELATIONSHIP BETWEEN POLYQ AGGREGATION AND TOXICITY

TRANSCRIPTIONAL DYSREGULATION BY POLYQ AGGREGATION

ROLE OF MOLECULAR CHAPERONES IN POLYQ AGGREGATION AND TOXICITY

ROLE OF THE UBIQUITIN-PROTEASOME SYSTEM IN POLYQ AGGREGATION AND TOXICITY

PERSPECTIVES

Colloquium Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases

CONCLUSION.

Colloquium Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity

METHODS

RESULTS AND DISCUSSION

Colloquium The insulation of genes from external enhancers and silencing chromatin

AN INSULATOR AS AN ENHANCER-BLOCKING ELEMENT

INSULATORS AS BARRIERS

CONCLUSION

Colloquium Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission

Colloquium Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion…

Colloquium Heritable chromatin structure: Mapping "memory" in histones H3 and H4

Colloquium Does heterochromatin protein 1 always follow code?

HP1 FOLLOWS CODE

ARE THERE MULTIPLE MECHANISMS FOR HP1 ASSOCIATION?

HP1 INTERACTS WITH A MYRIAD OF PROTEINS

HP1 REGULATES GENE EXPRESSION

Colloquium Self-perpetuating epigenetic pili switches in bacteria

CIS- AND TRANS-ACTING PAP SWITCH COMPONENTS

PAP PHASE VARIATION MODEL

SWITCH INPUTS

OUTPUTS

Colloquium Histone H3 variants specify modes of chromatin assembly

H3 VARIANTS DETERMINE THE NUCLEOSOME ASSEMBLY PATHWAY

CENTROMERES REPLICATE BEFORE THEIR SURROUNDING HETEROCHROMATIN

HIGH-RESOLUTION MAPPING OF CENTROMERE REPLICONS

INFERRING THE RI MACHINERY

OPENING A SPACE FOR HISTONE REPLACEMENT

THE RI TARGET SITES FOR H3 VARIANTS ARE IN DISTINCT NUCLEAR COMPARTMENTS

WHY RI ASSEMBLY?

CONCLUSIONS

Colloquium Induction and maintenance of nonsymmetrical DNA methylation in Neurospora

MAINTENANCE METHYLATION IN NEUROSPORA

CLUES TO INVOLVEMENT OF METHYL/RIP-DNA BINDING PROTEINS AND HISTONE DEACETYLATION IN DNA METHYLATION.

THE DIM-5 HISTONE METHYLTRANSFERASE INTEGRATES HISTONE CODE INFORMATION AND CONTROLS DNA METHYLATION

Colloquium Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes

Colloquium RNA-directed DNA methylation in Arabidopsis

EXPERIMENTAL PROCEDURES

Self-Perpetuating Structural States in Biology, Disease, and Genetics.

Notes:

"Arthur M. Sackler colloquia of the National Academy of Sciences."

Held in Washington, DC, on March 22-24, 2002.

Issued as: Proceedings of the National Academy of Sciences of the United States of America, v. 99, suppl. 4 (10 Dec. 2002).

Includes bibliographical references.

ISBN:

1-280-18368-3

9786610183685

0-309-57045-X

OCLC:

70723111