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Immunization safety review : thimerosal-containing vaccines and neurodevelopmental disorders / Kathleen Stratton, Alicia Gable, and Marie C. McCormick, editors ; Immunization Safety Review Committee, Board on Health Promotion and Disease Prevention, Institute of Medicine.

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Format:
Book
Contributor:
Stratton, Kathleen R.
Gable, Alicia.
McCormick, Marie C.
Institute of Medicine (U.S.). Immunization Safety Review Committee.
Series:
Compass series (Washington, D.C.)
The Compass series
Language:
English
Subjects (All):
Vaccination--Complications.
Vaccination.
Developmental disabilities--Etiology.
Developmental disabilities.
Organomercury compounds--Toxicology.
Organomercury compounds.
Physical Description:
1 online resource (136 p.)
Edition:
1st ed.
Place of Publication:
Washington, D.C. ; [Great Britain] : National Academy Press, c2001.
Language Note:
English
Summary:
In this report, the Immunization Safety Review committee examines the hypothesis of whether or not the use of vaccines containing the preservative thimerosal can cause neurodevelopmental disorders (NDDs), specifically autism, attention deficit/hyperactivity disorder (ADHD), and speech or language delay.
Contents:
IMMUNIZATION SAFETY REVIEW
Copyright
Acknowledgments
Contents
Executive Summary
PLAUSIBILITY ASSESSMENT
Biological Plausibility
Causality
SIGNIFICANCE ASSESSMENT
PUBLIC HEALTH RESPONSE
Policy Review and Analysis
Public Health and Biomedical Research
Epidemiological Research
Clinical Research
Basic Science Research
Communications
SUMMARY
REFERENCES
Immunization Safety Review: Thimerosal-Containing Vaccines and Neurodevelopmental Disorders
ORIGINS OF THE IMMUNIZATION SAFETY REVIEW PROJECT
THE CHARGE TO THE COMMITTEE
THE STUDY PROCESS
THE FRAMEWORK FOR ASSESSING CAUSALITY
UNDER REVIEW: THIMEROSAL-CONTAINING VACCINES AND NEURODEVELOPMENTAL DISORDERS
Thimerosal in Vaccines
Neurodevelopmental Disorders
Autism
Attention Deficit/Hyperactivity Disorder (ADHD)
Speech or Language Delay
Evidence Regarding Association: Biological Plausibility
Mercury Toxicokinetics
Comparisons of Ethylmercury and Methylmercury
Health Effects of High-Dose Exposures to Thimerosal, Ethylmercury, and Methylmercury
Health Effects of Low-Dose Exposures to Thimerosal and Methylmercury
Investigations Related to Mercury and Heavy Metals in Children with Autism
Application of Methylmercury Exposure Guidelines to Thimerosal Exposure from Vaccines
Biological Plausibility Argument
Evidence Regarding Association: Case Reports, Case Series, and Uncontrolled and Controlled Epidemiological Studies
Case Reports and Case Series
Epidemiological Studies
CAUSALITY ARGUMENT
Concern Regarding Neurodevelopmental Disorders
Continued Exposure to Thimerosal
Use of Thimerosal-Containing Vaccines in Other Countries
Confusion from Changes in Hepatitis B Immunization Policy
Trust in the Safety of Vaccines
Conclusion.
RECOMMENDATIONS REGARDING THE PUBLIC HEALTH RESPONSE
Clinical Studies
Basic Science Studies
Appendix A Immunization Safety Review: Measles-Mumps-Rubella Vaccine and Autism Executive Summary
OVERVIEW OF THE IMMUNIZATION SAFETY REVIEW PROJECT
THE HYPOTHESIZED RELATIONSHIP BETWEEN MMR AND AUTISM
RECOMMENDATIONS
Public Health Response
Policy Review
Research Regarding MMR and ASD
General and Crosscutting Issues
Appendix B Monday, July 16, 2001 Meeting Agenda
Appendix C Thimerosal Content in Licensed Vaccines
Appendix D Immunization Safety Review Committee Biosketches
Board on Health Promotion Disease Prevention Liaison.
Notes:
Bibliographic Level Mode of Issuance: Monograph
Includes bibliographical references.
ISBN:
9786610184187
9780309170376
0309170370
9781280184185
1280184183
9780309565738
0309565731
OCLC:
57005524

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