Chimpanzees in research : strategies for their ethical care, management, and use / Committee on Long-Term Care of Champanzees, Insitute for Laboratory Animal Research, Commission on Life Sciences, Nataional Research Council.

Format:

Book

Contributor:

Institute for Laboratory Animal Research (U.S.). Committee on Long-Term Care of Chimpanzees.

Series:

Compass series.

The Compass series

Language:

English

Subjects (All):

Chimpanzees--Research.

Chimpanzees.

Animal welfare--Moral and ethical aspects.

Animal welfare.

Physical Description:

1 online resource (108 p.)

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academy Press, 1997.

Language Note:

English

Summary:

Chimpanzees in biomedical and behavioral research constitute a national resource that has been valuable in addressing national health needs. Facilities that house chimpanzees owned and supported by the National Institutes of Health (NIH) have successfully met the research requirements of the scientific community. The captive chimpanzee population in the United States has grown substantially, particularly over the last decade. That growth is due primarily to the success of the NIH-sponsored Chimpanzee Breeding and Research Program, which achieved the birth numbers thought necessary to meet the projected needs of biomedical research. However, the expected level of use of the chimpanzee model in biomedical research did not materialize, and that has created a complex problem that threatens both the availability of chimpanzees for research in the future and the infrastructure required to ensure the well-being of captive chimpanzees used in biomedical research. Because the present system is fragmented, it is impossible to formulate an accurate overview of the size and nature of the chimpanzee population. But, if the chimpanzee is to continue to be used in biomedical research responsibly, effectively, and cost-effectively, we must be able to oversee, track, and coordinate the maintenance and use of chimpanzees and to control the size of the population. To assess the long-range situation and to develop, implement, and monitor the application of policies for the proper use and care of chimpanzees, an authoritative, centralized oversight structure is imperative. Once it is in place, it will be possible to refine and implement this report's recommendations.

Contents:

CHIMPANZEES IN RESEARCH

Copyright

PREFACE

Contents

CHIMPANZEES IN RESEARCH STRATEGIES FOR THEIR ETHICAL CARE, MANAGEMENT, AND USE

EXECUTIVE SUMMARY

1 INTRODUCTION

2 RESEARCH NEEDS

VALUE OF PAST STUDIES WITH CHIMPANZEES

INFECTIOUS DISEASE

XENOBIOTICS

FUTURE NEEDS FOR CHIMPANZEES

KNOWN INFECTIOUS AGENTS

HEPATITIS

RSV

HIV

MALARIA

EMERGING INFECTIOUS AGENTS

OTHER RESEARCH

MAXIMIZING THE AVAILABILITY OF CHIMPANZEES

TERMINAL STUDIES

CONCLUSIONS AND RECOMMENDATIONS

3 LONG-TERM CARE

HOUSING STANDARDS AND BEHAVIORAL WELL-BEING

HOUSING MODELS

PROVISIONS FOR BEHAVIORAL WELL-BEING

SPECIAL CONSIDERATIONS

EUTHANASIA

RECOMMENDATIONS FOR THE PRACTICE OF EUTHANASIA ENDORSED BY THE COMMITTEE

CHIMPANZEE POPULATION SUBGROUPS: DEFINITIONS AND RECOMMENDATIONS

GROUP A: BREEDING POPULATION

GROUP B: AVAILABLE FOR RESEARCH

GROUP C: CURRENTLY IN RESEARCH PROTOCOLS

GROUP D: NOT NEEDED FOR RESEARCH OR BREEDING

OWNERSHIP TRANSFER

CONCLUSIONS

4 DEMOGRAPHY, COST, AND GENETIC MATERIAL

DEMOGRAPHY

MODELS OF BREEDING COLONY SIZE

COSTS

PROJECTED BREEDING COLONY COSTS

REDUCING COSTS THROUGH SIMPLIFYING FUNDING AND ENHANCING COORDINATION

SANCTUARY CONSTRUCTION

GENETIC MANAGEMENT

FUTURE BREEDING

CRYOPRESERVATION OF GAMETES OR EMBRYOS

RECOMMENDATIONS

5 CENTRALIZATION OF RESEARCH CHIMPANZEE MANAGEMENT AND DEVELOPMENT OF A NATIONAL CHIMPANZEE RESOURCE

OWNERSHIP

FINANCIAL SUPPORT OF THE NATIONAL CHIMPANZEE RESOURCE (NCR)

PRIVATELY OWNED CHIMPANZEES IN BIOMEDICAL RESEARCH

CHIMPANZEE SANCTUARIES

THE NATIONAL CHIMPANZEE MANAGEMENT PROGRAM ADVISORY COUNCIL

CHARGE

DUTIES

MEMBERSHIP

REFERENCES

APPENDIX A MINORITY STATEMENT

REFERENCES.

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references.

ISBN:

9786610187089

9780309184762

0309184762

9781280187087

1280187085

9780309591157

0309591155

9780585002156

0585002150

OCLC:

42854089