Infectious diseases of mice and rats / Committee on Infectious Diseases of Mice and Rats, Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council.

Format:

Book

Author/Creator:

National Research Council (U.S.).

Language:

English

Subjects (All):

Mice--Infections.

Mice.

Rats--Infections.

Rats.

Laboratory animals--Infections.

Laboratory animals.

Mice as laboratory animals.

Rats as laboratory animals.

Physical Description:

1 online resource (409 pages)

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academy Press, 1991.

Language Note:

English

Summary:

This new edition--a must for all researchers who use these lab animals-- provides practical suggestions for breeding, keeping, and identifying pathogen-free laboratory rodents. It contains three informative sections. The first, "Principles of Rodent Disease Prevention, " summarizes methods for eliminating infectious agents. It offers information on pathogen terminology; pathogen status of rodents; and breeding, transporting, isolating, testing, and diagnosing rodents. The second section, "Individual Disease Agents and Their Effects on Research, " describes the diagnosis and control of each infectious agent, and the last section, "Diagnostic Indexes: Clinical Signs, Pathology, and Research Complications, " contains informative tables covering all the diseases listed in the volume, arranged to help in the diagnosis of infected animals.

Contents:

Infectious Diseases of Mice and Rats

Copyright

PREFACE

Contents

PART I PRINCIPLES OF RODENT DISEASE PREVENTION

1 Objectives, Terminology, and Overview of Pathogen Status

Scientific Objectives

Infection Versus Disease

Terminology of Microbial and Pathogen Status

Pathogen Status of Contemporary Rodents

2 Breeding, Transportation, and Use of Pathogen-free Rodents

3 Barrier Programs

Barrier Facilities

Barrier Rooms

Isolators as Barriers

Airflow Systems as Barriers

Barrier Cages

4 Health Surveillance Programs

Agent Detection Objectives

Test Procedures

Sampling Strategies

Test Frequency

Sentinel Animals

Rodent Diagnostic Laboratories

PART II INDIVIDUAL DISEASE AGENTS AND THEIR EFFECTS ON RESEARCH

5 Introduction

6 Respiratory System

Overview

Sendai Virus

Significance

Perspective

Agent

Hosts

Epizootiology

Clinical

Pathology

Diagnosis

Control

Interference with Research

Mycoplasma pulmonis

Cilia-Associated Respiratory Bacillus

Streptococcus pneumoniae

Corynebacterium kutscheri

Rat Coronavirus

Pneumonia Virus of Mice

Control.

Interference with Research

Mycobacterium avium-intracellulare

Pneumocystis carinii

Chlamydia trachomatis

Host

Chlamydia psittaci

Klebsiella pneumoniae

Streptococcus pyogenes

Mycoplasma neurolyticum

Mycoplasma collis

K Virus

7 Digestive System

Mouse Cytomegalovirus

Rat Cytomegalovirus

Mouse Thymic Virus

Clinical.

Pathology

Sialodacryoadenitis Virus

Mouse Hepatitis Virus

Mouse Rotavirus

Rat Rotavirus-Like Agent

Reovirus-3

Experimental Infections and Models

Natural Infections and Disease

Adenoviruses

Bacillus piliformis

Salmonella enteritidis

Citrobacter freundii (Biotype 4280)

Pseudomonas aeruginosa

COMMON ENDOPARASITES

Spironucleus muris.

Significance

Life Cycle

Giardia muris

Hymenolepis nana (Dwarf Tapeworm)

Syphacia obvelata (Mouse Pinworm) and Syphacia muris (Rat Pinworm)

Agents

Aspicularis tetraptera (mouse pinworm)

Entamoeba muris

Tritrichomonas muris

OTHER ENDOPARASITES

8 Skin and Joints

Ectromelia virus

Poxvirus(es) in Rats

Mycoplasma arthritidis

Streptobacillus moniliformis

Epizootiology.

Clinical

COMMON ECTOPARASITES

Myobia musculi

Myocoptes musculinus and Radfordia affinis

Other Ectoparasites

Staphylococcus aureus

Dermatophytes

Pasteurella pneumotropica

Mouse Papule Virus

Mouse Mammary Tumor Virus

Self-Mutilation Associated with Otitis Media

NONINFECTIOUS SKIN CONDITIONS IMPORTANT IN DIFFERENTIAL DIAGNOSIS

Bite Wounds in Adult Mice and Rats

Bite Wounds in Weanling Mice

Whisker-Trimming," "Hair-Nibbling," and "Barbering

Muzzle Alopecia

Hair Growth Cycling Arrest

Ringtail

9 Hemopoietic System

Lymphocytic Choriomeningitis Virus

Lactic Dehydrogenase-Elevating Virus

Pathology.

Diagnosis.

Notes:

"An expansion of the newly revised second edition of the Companion guide to infectious diseases of mice and rats"--P. vii.

Includes bibliographical references (p. 277-385) and index.

ISBN:

9786610186266

9781280186264

1280186267

9780309556927

0309556929

9780585060279

0585060274

OCLC:

427404670