Scientific frontiers in developmental toxicology and risk assessment / Committee on Developmental Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council.

Format:

Book

Contributor:

National Research Council (U.S.). Committee on Developmental Toxicology.

National Research Council (U.S.). Commission on Life Sciences.

Language:

English

Subjects (All):

Developmental toxicology.

Abnormalities, Human--Risk factors.

Abnormalities, Human.

Health risk assessment.

Physical Description:

1 online resource (348 p.)

Edition:

1st ed.

Place of Publication:

Washington, DC : National Academy Press, c2000.

Language Note:

English

Summary:

Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Contents:

""Cover""; ""Front Matter""; ""Preface""; ""Contents""; ""List of Abbreviations""; ""Executive Summary""; ""1 Introduction""; ""2 Developmental Defects and Their Causes""; ""3 Current Practices for Assessing Risk for Developmental Defects and Their Limitations""; ""4 Mechanisms of Developmental Toxicity""; ""5 Human Genetics and the Human Genome Project""; ""6 Recent Advances in Developmental Biology""; ""7 Using Model Animals to Assess and Understand Developmental Toxicity""; ""8 A Multilevel Approach to Improving Risk Assessment for Developmental Toxicity""

""9 Conclusions and Recommendations""""References""; ""Appendixes""; ""Appendix A Glossary""; ""Appendix B Database Descriptions""; ""Appendix C Signaling Pathways""; ""Appendix D Biographical Information on the Committee on Developmental Toxicology""; ""Index""

Notes:

Description based upon print version of record.

Includes bibliographical references (p. 245-277) and index.

ISBN:

9780309171809

0309171806

9780309501767

0309501768

OCLC:

923256333