Re-evaluation of drinking-water guidelines for disopropyl methylphosphonate / Subcommitee on the Toxicity of Diisopropyl Methylphosphonate, Committee on Toxicity, Board on Environmental Studies and Toxicity, Commission on Life Sciences, National Research Council.

Format:

Book

Author/Creator:

National Research Council (U.S.). Subcommittee on the Toxicity of Diisopropyl Methylphosphonate.

Series:

Compass series (Washington, D.C.)

The Compass series

Language:

English

Subjects (All):

Diisopropyl methylphosphonate--Toxicology.

Diisopropyl methylphosphonate.

Sarin--Derivatives--Toxicology.

Sarin.

Physical Description:

1 online resource (48 p.)

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academy Press, c2000.

Language Note:

English

Summary:

Diisopropyl Methylphosphonate (DIMP) is a groundwater contaminant at the U.S. Army's Rocky Mountain Arsenal in Colorado. DIMP is a by-product created from the manufacture and detoxification of the nerve agent GB which the arsenal produced from 1953 to 1957. For awhile the Army and the State of Colorado disagreed upon the appropriate drinking-water contaminant guideline for DIMP. A drinking-water guideline of 600 micrograms per liter was established by the U.S. Environmental Protection Agency (EPA) in 1989 but the State of Colorado promulgated a lower guideline of 8 micrograms per liter. The significant difference between the two suggested values arose from the fact that both sides used different studies to determine their values. Colorado used one-generation reproductive toxicity study in mink, whereas EPA used a subchronic toxicity study in dogs. To resolve the disagreement, a two-generation reproductive study in mink was conducted. The Army asked the National Research Council (NRC) to independently evaluate the 1997 study and re-evaluate the drinking-water guideline for DIMP. This task was assigned to the Committee on Toxicology, which established the Subcommittee on the Toxicity of Diisopropyl Methylphosphonate, a multidisciplinary group of experts. The subcommittee evaluated the two-generation reproductive study as well as other studies relevant to the task. Data on the use of mink as a predictive model in toxicology were also reviewed . Re-Evaluation of Drinking-Water Guidelines for Diisopropyl Methylphosphonate is the subcommittee's report which shows that neither party was corrected in their DIMP guidelines. The report includes the subcommittee's evaluation and recommendations concerning the topic.

Contents:

""RE-EVALUATION OF DRINKING-WATER GUIDELINES FOR DIISOPROPYL METHYLPHOSPHONATE""; ""Copyright""; ""OTHER REPORTS OF THE BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY""; ""OTHER REPORTS OF THE COMMITTEE ON TOXICOLOGY""; ""Preface""; ""Contents""; ""Executive Summary""; ""Introduction""; ""Evaluation""; ""ONE-GENERATION REPRODUCTIVE TOXICITY STUDY""; ""TWO-GENERATION REPRODUCTIVE TOXICITY STUDY""; ""SUBCHRONIC TOXICITY STUDY""; ""COMPARATIVE METABOLISM STUDY""; ""Observations in Mink""; ""Observations in Rats""; ""Other Noteworthy Points""; ""TOXIC POTENTIAL DIMP METABOLITES""

""COMPARISON OF MINK AND OTHER TEST ANIMALS""""DRINKING-WATER GUIDELINES FOR DIMP""; ""References""; ""Appendix BIOGRAPHICAL INFORMATION ON THE SUBCOMMITTEE ON THE TOXICITY OF DIISOPROPYL METHYLPHOSPHONATE""

Notes:

Description based upon print version of record.

Includes bibliographical references (p. 27-29).

ISBN:

9786610185269

9780309183949

0309183944

9781280185267

1280185260

9780309563338

030956333X

OCLC:

923268825