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Health effects of ingested fluoride / Subcommittee on Health Effects of Ingested Fluoride, Committee on Toxicology, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council.
- Format:
- Book
- Author/Creator:
- National Research Council (U.S.). Subcommittee on Health Effects of Ingested Fluoride.
- Language:
- English
- Subjects (All):
- Fluorides--Toxicology.
- Fluorides.
- Fluorides--Metabolism.
- Fluorides--Physiological effect.
- Water--Fluoridation--Health aspects.
- Water.
- Physical Description:
- 1 online resource (197 p.)
- Edition:
- 1st ed.
- Place of Publication:
- Washington, D.C. : National Academy Press, 1993.
- Language Note:
- English
- Summary:
- This book reviews the effects on health of fluoride ingested from various sources. Those health effects reviewed include dental fluorosis; bone fracture; effects on renal, reproductive, and gastrointestinal systems; and genotoxicity and carcinogenicity. The book also reviews the Environmental Protection Agency's current drinking-water standard for fluoride and considers future research needs.
- Contents:
- Health Effects of Ingested Fluoride
- Copyright
- Preface
- Contents
- Health Effects of Ingested Fluoride
- Executive Summary
- INTRODUCTION
- INTAKE, METABOLISM, AND DISPOSITION OF FLUORIDE
- DENTAL FLUOROSIS
- FLUORIDE AND BONE FRACTURES
- EFFECTS OF FLUORIDE ON THE RENAL SYSTEM
- EFFECTS OF FLUORIDE ON THE GASTROINTESTINAL SYSTEM
- EFFECTS OF FLUORIDE ON HYPERSENSITIVITY AND THE IMMUNE SYSTEM
- EFFECTS OF FLUORIDE ON REPRODUCTION
- GENOTOXICITY
- CARCINOGENICITY
- CONCLUSIONS
- 1 Introduction
- 2 Dental Fluorosis
- THE FLUORIDE CONTENT OF TEETH
- FLUORIDE'S ACTION IN PREVENTING DENTAL CARIES
- HISTOPATHOLOGY OF DENTAL FLUOROSIS
- DIAGNOSTIC ISSUES IN DENTAL FLUOROSIS
- INDEXES FOR DENTAL FLUOROSIS
- DENTAL FLUOROSIS AND FLUORIDE INTAKE
- PREVALENCE OF DENTAL FLUOROSIS
- RISK FACTORS IN DENTAL FLUOROSIS
- THE RELATION BETWEEN DENTAL FLUOROSIS AND CARIES
- RESEARCH RECOMMENDATIONS
- 3 Fluoride Exposure and Risk of Bone Fracture
- BONE FRACTURE IN HUMANS
- Clinical Trials of Fluoride
- Population Studies
- Studies Using Information from Individuals
- Studies Using Population Characteristics
- Skeletal Fluorosis
- Discussion
- BONE FRACTURE IN ANIMALS
- 4 Reproductive Effects of Fluoride
- REPRODUCTIVE EFFECTS IN HUMANS
- REPRODUCTIVE EFFECTS IN ANIMALS
- DISCUSSION
- 5 Effects of Ingested Fluoride on Renal, Gastrointestinal, and Immune Systems
- EFFECTS ON THE RENAL SYSTEM
- EFFECTS ON THE GASTROINTESTINAL SYSTEM
- HYPERSENSITIVITY AND IMMUNOLOGICAL EFFECTS
- 6 Genotoxicity of Fluoride
- IN VITRO GENOTOXICITY TEST SYSTEMS
- Microbes
- Mammalian Cells
- Gene Mutations
- Chromosomal Aberrations and Sister Chromatid Exchanges
- Animal Cells
- Human Cells
- DNA Damage and Repair
- Transformation
- Discussion.
- IN VIVO GENOTOXICITY TEST SYSTEMS
- Drosophila
- Rodents
- Somatic Cells
- Germ Cells
- Human Studies
- PROPOSED MECHANISMS OF GENOTOXICITY
- SUMMARY
- 7 Carcinogenicity of Fluoride
- FLUORIDE CARCINOGENCITY IN HUMANS
- FLUORIDE CARCINOGENICITY IN ANIMALS
- Early Toxicological Studies Of Fluoride and Cancer
- Recent Carcinogenicity Bioassays
- RECOMMENDATIONS
- 8 Intake, Metabolism, and Disposition of Fluoride
- FLUORIDE INTAKE
- FLUORIDE ABSORPTION
- FLUORIDE IN PLASMA
- TISSUE DISTRIBUTION
- FLUORIDE EXCRETION
- References
- Appendix 1 Criteria for Dean's Index, TF Index, and TSIF
- Appendix 2 Letter to AFIP
- Appendix 3 AFIP Response.
- Notes:
- Project was supported by the U.S. Environmental Protection Agency under contract CR-819504-01-0.
- Subcommittee chairman: Bernard M. Wagner.
- Includes bibliographical references (p. 135-166).
- ISBN:
- 9786610211333
- 9781280211331
- 1280211334
- 9780309596381
- 0309596386
- 9780585028729
- 0585028729
- OCLC:
- 42329401
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