Complex mixtures : methods for in vivo toxicity testing / Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council.

Format:

Book

Contributor:

National Research Council (U.S.). Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures.

Language:

English

Subjects (All):

Toxicity testing--Evaluation.

Toxicity testing.

Toxicology, Experimental.

Physical Description:

1 online resource (xi, 227 pages) : illustrations

Edition:

1st ed.

Place of Publication:

Washington, D.C. : National Academy Press, 1988.

Language Note:

English

Summary:

Addresses the problem of identifying and classifying complex mixtures, investigating the effect of exposure, and the research problems inherent in testing their toxicity to human beings. A series of case studies is presented, including one that examines the cofactors of alcohol consumption and cigarette smoke.

Contents:

1 Front Matter; 2 Executive Summary; 3 1. Introduction; 4 2. Concepts for Analyzing Human Exposure to Complex Chemical Mixtures; 5 3. Testing Strategies and Methods; 6 4. Sampling and Chemical Characterization; 7 5. Interpretation and Modeling of Toxicity-Test Results; 8 Appendix A: Origins of Complex Mixtures; 9 Appendix B: Case Studies Establishing Active Agents and/or Interactions in Complex Mixtures; 10 Appendix C: Case Studies on Strategies for Testing the Toxicity of Complex Mixtures; 11 Appendix D: Predicting the Joint Risk of a Misture in Terms of the Component Risks; 12 Appendix E: Cancer Models; 13 Appendix F: Developmental Toxicology; 14 Appendix G: Empirical Modeling of the Toxicity of Mixtures; 15 Index

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographies and index.

ISBN:

9786610221639

9781280221637

1280221631

9780309555135

0309555132

9780585144603

0585144605

OCLC:

427404809