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Biologic markers in reproductive toxicology / Subcommittee on Reproductive and Neurodevelopmental Toxicology, Committee on Biologic Markers, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council.

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National Academies Press Available online

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Format:
Book
Author/Creator:
Subcommittee on Reproductive and Neurodevelopmental Toxicology, Committee on Biologic Markers, Board on Environmental Studies and Toxicology, Commission on Life Sciences, National Research Council, author, issuing body.
Division on Earth and Life Studies, author.
Commission on Life Sciences, author.
Board on Environmental Studies and Toxicology, author.
Committee on Biologic Markers, author.
Subcommittee on Reproductive and Neurodevelopmental Toxicology, author.
Contributor:
Division on Earth and Life Studies, author.
Commission on Life Sciences, author.
Board on Environmental Studies and Toxicology, author.
Committee on Biologic Markers, author.
Subcommittee on Reproductive and Neurodevelopmental Toxicology, author.
Language:
English
Subjects (All):
Reproductive toxicology.
Biochemical markers.
Physical Description:
1 online resource (xxi, 395 pages) : illustrations
Edition:
1st ed.
Place of Publication:
Washington, D.C. : National Academy Press, 1989.
Summary:
Examines the potential use of these markers in environmental health studies, and clarifies definitions, underlying concepts, and possible applications. Acidic paper. Annotation(c) 2003 Book News, Inc., Portland, OR (booknews.com).
Contents:
Executive summary
Report of the Oversight Committee. I. Biologic markers in male reproductive and gametic genetic toxicology. Introduction
Clinical evaluation of male infertility
Biologic markers of testicular function
Biologic markers of epididymal structure and function
Biologic markers of accessory sex organ structure and function
Biologic markers of human male reproductive health and physiologic damage
Assessing transmitted mutations in mice
Markers for measuring germinal genetic toxicity and heritable mutations in people
Conclusions and recommendations. II. Biologic markers in female reproductive toxicology. Introduction
Biologic markers of genetic damage in females
Biologic markers of reproductive development and aging
Biologic markers of nonconceptive menstrual cycles
Developing assays of biologic markers for epidemiologic studies: experience with a marker of pregnancy and early loss
Conclusions and recommendations. III. Biologic markers of toxicity during pregnancy. Introduction
Molecular biology: developing DNA markers of genotoxic effects
Reproductive immunology: biologic markers of compromised pregnancies
Cell biology: identifying biologic markers expressed during early pregnancy
Physiologic assessment of fetal compromise
Conclusions and Recommendations. IV. Biologic Markers in Neurodevelopmental Toxicology. Introduction
Developmental neurobiology of the central nervous system
Morphologic, neurochemical, and behavioral responses to toxic agents
Methodologic issues of extrapolation from animal studies to human toxicant exposure
Lead as a paradigm for the study of neurodevelopmental toxicology
Conclusions and recommendations
Appendix: Assessing the validity of biologic markers: alpha-fetoprotein
References
Biographies
Index.
Notes:
Includes bibliography (p. 319-372) and index.
Includes index.
ISBN:
9786610214747
9781280214745
1280214740
9780309568142
0309568145
9780585143910
0585143919
OCLC:
726823183

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