Medically assisted conception : an agenda for research : report of a study by a committee of the Institute of Medicine, Division of Health Sciences Policy [and] National Research Council, Board on Agriculture.an agenda for research.

Format:

Book

Author/Creator:

Committee on the Basic Science Foundations of Medically Assisted Conception.

Contributor:

Institute of Medicine (U.S.). Division of Health Sciences Policy.

National Research Council (U.S.). Board on Agriculture.

Series:

IOM publication ; 89-008.

Language:

English

Subjects (All):

Reproductive technology.

Artificial insemination.

Physical Description:

1 online resource (viii, 361 pages) : illustrations.

Edition:

1st ed.

Place of Publication:

Washington, D.C. ; [England] : National Academy Press, 1989.

Language Note:

English

Summary:

This book results from a study by a committee of the Institute of Medicine and the National Research Council's Board on Agriculture. The committee examined the scientific foundations of medically assisted conception and developed an agenda for basic research in reproductive and developmental biology that would contribute to advances in the clinical and agricultural practice of "in vitro" fertilization and embryo transfer. The volume also discusses some barriers to progress in research and ways of lowering them, and explains the scientific issues important to ethical decision making.

Contents:

Medically Assisted Conception

Copyright

Contents

Acknowledgements

Preface

SCOPE OF THE STUDY

Summary

SOCIAL CONCERNS THAT CAN BE ADDRESSED BY IVFET

BARRIERS TO PROGRESS IN IN VITRO FERTILIZATION AND EMBRYO TRANSFER

Ethical And Social Issues

The Federal Government And Embryo Research

Domestic And Foreign Decisions Concerning Embryo Research

Other Barriers To Scientific Progress

RESEARCH AGENDA

Basic Science

Male Gametogenesis

Female Gametogenesis

Fertilization

Preimplantation Development

Implantation

Technological Advances

Clinical Research Opportunities

CONCLUSIONS AND RECOMMENDATIONS

Developing Research Policy

Basic Science Foundations

Applied Research

Improving Communications

REFERENCES

Chapter 1 In Vitro Fertilization And Embryo Transfer And Social Concerns

INFERTILITY

Treatments For Infertility

In Vitro Fertilization And Embryo Transfer

Gamete Intrafallopian Transfer

Donated Gametes Or Concepti

CONTRACEPTION

AGRICULTURE

BIODIVERSITY

PRIMATES FOR RESEARCH

Chapter 2 Advances In The Practice And Science Base Of Medical, Assisted Conception

DEVELOPMENTS IN HUMAN IN VITRO FERTILIZATION [ 1 ]

DEVELOPMENTS IN ASSISTED CONCEPTION IN FOOD-PRODUCING ANIMALS [ 2 ]

GAMETOGENESIS AND GAMETES

Induction Of Gametogenesis And Superovulation [ 3 ]

Biology And Maturation [ 4 ]

Intratesticular And Intraovarian Paracrine Control [ 5 ]

Assessment Of Gametes [ 6 ]

FERTILIZATION [ 7 ]

PREIMPLANTATION DEVELOPMENT [ 8 ]

Metabolic Substrates And Pathways

Gene Expression In Early Embryonic Development

Regulative Potential Of Micromanipulated Embryos

IMPLANTATION [ 9 ]

ENDNOTES

Chapter 3 Barriers To Progress In In Vitro Fertilization And Embryo Transfer.

ETHICAL AND SOCIAL ISSUES

Domestic And Foreign Decisions On Embryo Research

OTHER BARRIERS TO SCIENTIFIC PROGRESS

Deficiencies In The Science Base

Research Funding

Lack Of Communication Among Researchers

Societal Concerns

Sources Of Research Material

Chapter 4 Research Agenda And Recommendations

Appendix A Committee On Basic Science Foundations Of Medically Assisted Conception

TECHNOLOGIES FOR ASSISTED CONCEPTION/EMBRYO TRANSFER IN AGRICULTURAL AND VETERINARY PRACTICE

Introduction

Artificial Insemination

Superovulation

Embryo Transfer

Freezing Of Embryos

Sexing Of Embryos

Sexing By Y Chromosome Specific Dna Hybridization

Multiplication Of Embryos

Nuclear Transfer

In Vitro Production Of Embryos

Oocyte Maturation

In Vitro Fertilization

Development Of Embryos In Vitro

Gene Transfer

Conclusions

References

OVARIAN STIMULATION IN NON-HUMAN PRIMATES

The Menstrual Cycle

Regulation Of Folliculogenesis

Ovarian Stimulation

Problems With Stimulated Ovarian Function

Solutions For Problems With Stimulated Ovarian Function

Acknowledgement

RESPONSES TO GONADOTROPINS IN DOMESTIC ANIMALS

Superovulation In Domestic Animals

Superovulation Of Cattle

Superovulation Of Sheep And Goats

Effects Of Exogenous Gonadotropins On Horses

Ovulation Induction In Pigs.

Recommendations For Future Directions In Research

MEMBRANE MODELS: EVOLUTION FROM THE FLUID-MOSAIC STANDBY ROY HAMMERSTEDT

Complexity Of The Cell Surface

Asymmetry Of Cell Surfaces

Lipid Domains

Relative Speed Of Membrane Events

Spatial Relationships On The Membrane Surface

MAMMALIAN OOCYTE MATURATION: MECHANISMS FOR REGULATION AND PROSPECTS FOR PRACTICAL APPLICATION OF IN VITRO TECHNOLOGY

The Ovarian Follicle As The Support System For Oocyte Development In Vivo

Identification Of Molecules And Pathways That Participate In The Maintenance Of Meiotic Arrest

Induction Of Oocyte Maturation

Similarities Between Mechanisms That Govern Meiotic and Mitotic Cell Division

Murine Oocyte Growth And Development In Culture

Prospects For The Practical Utilization Of Oocyte Culture Systems

Expansion Of Populations Of Rare Or Agriculturally Important Mammals

Acknowledgments

INTRAGONADAL CONTROL OF TESTIS FUNCTION

Summary And Conclusions

PARACRINE REGULATION IN THE OVARY

Intraovarian Steroids

The Role Of Ovarian Growth Factors

Other Regulatory Peptides In The Ovarian Follicle

Summary Of Current Efforts And Future Perspectives

Literature Cited

EXPERIMENTAL APPROACHES TO THE STUDY OF EARLY DEVELOPMENTAL FAILURE IN HUMAN REPRODUCTION

Early Developmental Failure In The Human

The Frequency Of Chromosomal Anomalies In Human Oocytes After Ovarian Hyperstimulation

Developmental Failure During The Perifertilization Period

Figure Legends

THE FERTILIZING SPERM: STRUCTURE, MATURATION AND FUNCTION

Sperm Structure.

Common Themes In The Cellular Sequence Of Gamete Interaction

A General Model For Mammallan Gamete Interaction

Common Themes During Epididymal Transit

For What Types Of Studies Are Model Systems Appropriate?

Reviews to consult for detailed information and references

MOLECULAR EVENTS PRE-AND POST-FERTILIZATION OF MOUSE EGGS: OOCYTE MATURATION, EGG ACTIVATION, AND POLYSPERMY BLOCK

Acquisition Of Meiotic Competence

1. Role Of Camp And Protein Phosphorylation

2. Maturation Promoting Factor

3. Acquisition And Maintenance Of Sperm Decondensing Activity

Fertilization And Egg Activation

1. Block To Polyspermy

Unresolved Questions And Future Directions

GLYCOLYTIC PATHWAY IN PREIMPLANTATION MAMMALIAN EMBRYOS

Evidence That Metabolic Pathways Are Respricted In Oogenesis And Early Mammalian Development

Morphology Of The Mitochondria During Oogenesis And Preimplantation Development

Nutritional Studies With Chemically Defined Media

Uptake Of Metabolic Substrates

Metabolic Fate Of Substrates

A Caveat-Be Alert For Artifacts

Metabolic Fate Of Glucose

Control Of Glycolysis

Conclusion

REGULATIVE POTENTLAL OF MICROMANIPULATED EMBRYOS

Uses Of Micromanipulation

Types Of Manipulation

Regulation In Mammalian Embryos

Use Of Micromanipulation In Studying Regulation In Laboratory And Domestic Species

Regulation And Cell Potential During Cleavage And Blastulation

How Is Relation Accomplished?

UTERINE RECEPTIVITY, MATERNAL RECOGNITION OF PREGNANCY AND EARLY EMBRYONIC LOSS

Magnitude Of Embryonic Losses

Causes Of Embryonic Loss

Implantation And Placentation.

Asynchrony Of Embryo And Mother Is Related To Early Embryonic Loss

The Necessity Of The Uterine Environment

Maternal Recognition Of Pregnancy And Pregnancy Failure

Immunological Rejection Of Embryos

Natural Asynchrony And Embryonic Loss

Legend to Figure

TOWARDS A CELLULAR AND MOLECULAR UNDERSTANDING OF IMPLANTATION IN THE HUMAN: IMPLICATIONS FOR ASSISTED REPRODUCTIVE…

Preparation And Characterization Of Human Cytotrophoblasts

Trophoblast Aggregation

Trophoblast Fusion

Trophoblast Interactions With Extracellular Matrix

Relationship Between Morphologic And Functional Differentiation Of The Trophoblast

Interactions Between Trophoblast And Endometrium

Cytotrophoblast Interactions With Endometrial Explants

Cytotrophoblast Interactions With Endometrial Glandular Epithelium And Stroma

Trophoblast Invasion Into The Endometrium

Paracrine Interactions During Implantation

A Working Model For Implantation In The Human And Future Directions For Research

References.

Notes:

Bibliographic Level Mode of Issuance: Monograph

Includes bibliographical references.

ISBN:

1-280-21428-7

9786610214280

0-309-55983-9

0-585-15416-3

OCLC:

726823042